Weinstein I B
J Cell Biochem. 1987 Mar;33(3):213-24. doi: 10.1002/jcb.240330308.
This paper presents evidence that the full repertoire of cellular genes involved in the carcinogenic process is several times larger than that of the known list of proto-oncogenes. Furthermore, this repertoire includes genes whose normal function is related to growth stimulation, as well as genes whose normal function is to inhibit growth or induce terminal differentiation. Multistage carcinogenesis probably results from a complex series of changes in both categories of genes. Despite this complexity, carcinogenesis can be conceived in terms of disturbances in biochemical functions that normally control the expression or function of growth factors, receptors, and pathways of signal transduction. Several protein kinases play a central role in the process of signal transduction. Our laboratory has recently isolated cDNA clones for the enzyme protein kinase C (PKC). These clones should be useful for clarifying the role of PKC in growth control and tumor promotion. Finally, the existence of genes whose normal function is to inhibit cell growth provides a rationale for new strategies of cancer prevention and treatment.
本文提出证据表明，参与致癌过程的细胞基因全套比已知的原癌基因列表要大几倍。此外，这个全套包括正常功能与生长刺激相关的基因，以及正常功能是抑制生长或诱导终末分化的基因。多阶段致癌作用可能源于这两类基因的一系列复杂变化。尽管存在这种复杂性，但致癌作用可以从正常控制生长因子、受体和信号转导途径的表达或功能的生化功能紊乱方面来理解。几种蛋白激酶在信号转导过程中起核心作用。我们实验室最近分离出了酶蛋白激酶C（PKC）的cDNA克隆。这些克隆对于阐明PKC在生长控制和肿瘤促进中的作用应该是有用的。最后，正常功能是抑制细胞生长的基因的存在为癌症预防和治疗的新策略提供了理论依据。
