癌症模型概述
A hitchhiker's guide to cancer models.
机构信息
CerFlux, Inc., Birmingham, AL, USA; Department of Radiation Oncology, Heersink School of Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA; Department of Physics, Coe College, Cedar Rapids, IA, USA.
CerFlux, Inc., Birmingham, AL, USA.
出版信息
Trends Biotechnol. 2022 Nov;40(11):1361-1373. doi: 10.1016/j.tibtech.2022.04.003. Epub 2022 May 7.
Cancer is a complex and uniquely personal disease. More than 1.7 million people in the United States are diagnosed with cancer every year. As the burden of cancer grows, so does the need for new, more effective therapeutics and for predictive tools to identify optimal, personalized treatment options for every patient. Cancer models that recapitulate various aspects of the disease are fundamental to making advances along the continuum of cancer treatment from benchside discoveries to bedside delivery. In this review, we use a thought experiment as a vehicle to arrive at four broad categories of cancer models and explore the strengths, weaknesses, opportunities, and threats for each category in advancing our understanding of the disease and improving treatment strategies.
癌症是一种复杂的、具有独特个体差异的疾病。每年，美国有超过 170 万人被诊断患有癌症。随着癌症负担的增加，我们需要新的、更有效的治疗方法和预测工具，以确定每个患者的最佳、个性化的治疗方案。能够重现疾病各个方面的癌症模型是癌症治疗从实验室发现到临床应用的连续体上取得进展的基础。在这篇综述中，我们使用思维实验作为一种手段，将癌症模型分为四大类，并探讨了每种类别在提高我们对疾病的认识和改善治疗策略方面的优势、劣势、机遇和威胁。
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