Chen Mian, Zhang Jiangjiang, Qi Jie, Dong Ruihua, Liu Hongmei, Wu Decheng, Shao Huawu, Jiang Xingyu
Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088, Xueyuan Road, Xili, Nanshan District, Shenzhen, Guangdong 518055, People's Republic of China.
Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People's Republic of China.
ACS Nano. 2022 May 24;16(5):7732-7744. doi: 10.1021/acsnano.1c11613. Epub 2022 May 10.
Metal-organic frameworks (MOFs) are promising photosensitized materials that have displayed great advantages in antibacterial application. However, their bactericidal activity is still limited by the ultrashort diffusion distance of biocidal reactive oxygen species (ROS). Herein, we integrate the bacterial-binding boronic acid ligand and photosensitized porphyrin into one single MOF, synergistically boosting antibiotic capability. The introduction of the boronic acid group with a closed physical gap makes multivariate MOFs more powerful for eradicating multi-drug-resistant (MDR) bacteria. The MOFs that are decorated with boronic acid possess antibacterial efficiencies (10-20 times) higher than those without the targeting ligand. Moreover, the MOFs exhibit excellent biocompatibility. They significantly decrease the inflammatory responses and accelerate the healing of chronic wounds infected with MDR bacteria (nearly 2 times faster). This work provides a strategy to develop multivariate MOFs that target bacteria, which will further inspire specific bacterial-binding therapy in the future.
金属有机框架材料（MOFs）是很有前景的光敏材料，在抗菌应用中已展现出巨大优势。然而，其杀菌活性仍受限于生物活性氧（ROS）的超短扩散距离。在此，我们将细菌结合硼酸配体和光敏卟啉整合到单一MOF中，协同增强抗菌能力。具有封闭物理间隙的硼酸基团的引入，使多元MOFs在根除多重耐药（MDR）细菌方面更具效力。装饰有硼酸的MOFs的抗菌效率比没有靶向配体的MOFs高（10 - 20倍）。此外，MOFs表现出优异的生物相容性。它们显著降低炎症反应，并加速感染MDR细菌的慢性伤口的愈合（快近2倍）。这项工作提供了一种开发靶向细菌的多元MOFs的策略，这将在未来进一步激发特异性细菌结合疗法。
