Acta Biochim Biophys Sin (Shanghai). 2022 Feb 25;54(2):153-162. doi: 10.3724/abbs.2021022.
With high incidence rate, cancer is the main cause of death in humans. Non-coding RNAs, as novel master regulators, especially long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play important roles in the regulation of tumorigenesis. lncRNA NEAT1 has recently gained much attention, as it is dysregulated in a broad spectrum of cancers, where it acts as either an oncogene or a tumor suppressor gene. Accumulating evidence shows that NEAT1 is correlated with the process of carcinogenesis, including proliferation, invasion, survival, drug resistance, and metastasis. NEAT1 is considered to be a biomarker and a novel therapeutic target for the diagnosis and prognosis of different cancer types. The mechanisms by which NEAT1 plays a critical role in cancers are mainly via interactions with miRNAs. NEAT1-miRNA regulatory networks play significant roles in tumorigenesis, which has attracted much attention from researchers around the world. In this review, we summarize the interaction of NEAT1 with miRNAs in the regulation of protein-coding genes in cancer. A better understanding of the NEAT1-miRNA interactions in cancer will help develop new diagnostic biomarkers and therapeutic approaches.
癌症发病率高，是导致人类死亡的主要原因。非编码 RNA 作为新型的主要调控因子，尤其是长非编码 RNA（lncRNA）和 microRNA（miRNA），在肿瘤发生的调控中发挥重要作用。lncRNA NEAT1 最近受到广泛关注，因为它在广泛的癌症中失调，作为癌基因或肿瘤抑制基因发挥作用。越来越多的证据表明，NEAT1 与致癌过程有关，包括增殖、侵袭、存活、耐药和转移。NEAT1 被认为是不同癌症类型的诊断和预后的生物标志物和新型治疗靶点。NEAT1 在癌症中发挥关键作用的机制主要是通过与 miRNAs 的相互作用。NEAT1-miRNA 调控网络在肿瘤发生中起着重要作用，引起了世界各地研究人员的关注。在这篇综述中，我们总结了 NEAT1 与 miRNA 相互作用在癌症中对编码蛋白基因的调控。更好地理解癌症中 NEAT1-miRNA 相互作用将有助于开发新的诊断生物标志物和治疗方法。
