Department of Biological Sciences and KI for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Republic of Korea.
Sci Data. 2022 May 10;9(1):197. doi: 10.1038/s41597-022-01308-3.
The gut microbiota is associated with the health and longevity of the host. A few methods, such as fecal microbiota transplantation and oral administration of probiotics, have been applied to alter the gut microbiome and promote healthy aging. The changes in host microbiomes still remain poorly understood. Here, we characterized both the changes in gut microbial communities and their functional potential derived from colon samples in mouse models during aging. We achieved this through four procedures including co-housing, serum injection, parabiosis, and oral administration of Akkermansia muciniphila as probiotics using bacterial 16 S rRNA sequencing and shotgun metagenomic sequencing. The dataset comprised 16 S rRNA sequencing (36,249,200 paired-end reads, 107 sequencing data) and metagenomic sequencing data (307,194,369 paired-end reads, 109 sequencing data), characterizing the taxonomy of bacterial communities and their functional potential during aging and rejuvenation. The generated data expand the resources of the gut microbiome related to aging and rejuvenation and provide a useful dataset for research on developing therapeutic strategies to achieve healthy active aging.
肠道微生物群与宿主的健康和长寿有关。一些方法，如粪便微生物群移植和口服益生菌，已被应用于改变肠道微生物群，促进健康衰老。宿主微生物组的变化仍知之甚少。在这里，我们通过包括共饲养、血清注射、联体共生和口服黏蛋白阿克曼氏菌作为益生菌在内的四个程序，对衰老过程中来自小鼠模型的结肠样本中的肠道微生物群落及其功能潜力的变化进行了描述。我们使用细菌 16S rRNA 测序和 shotgun 宏基因组测序实现了这一点。该数据集包括 16S rRNA 测序（36249200 对末端读取，107 个测序数据）和宏基因组测序数据（307194369 对末端读取，109 个测序数据），描述了细菌群落的分类和它们在衰老和恢复活力过程中的功能潜力。生成的数据扩展了与衰老和恢复活力相关的肠道微生物组资源，并为开发实现健康活跃衰老的治疗策略的研究提供了有用的数据集。
