Chen Yu, Lu Weipeng, Guo Yanchuan, Zhu Yi, Lu Haojun, Wu Yuxiao
Hangzhou Research Institute of Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Hangzhou 310018 China
Key Laboratory of Photochemical Conversion and Optoelectronic Material, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Beijing 100190 China.
RSC Adv. 2018 Jun 29;8(42):23712-23719. doi: 10.1039/c8ra04066d. eCollection 2018 Jun 27.
As a degradable natural biomaterial, gelatin has good biocompatibility and nontoxicity, but gelatin is easily soluble in water which has limited its application. In order to solve this tough defect, superhydrophobic gelatin films (GSF) were prepared by first grafting silica nanoparticles onto gelatin films and then modifying silica nanoparticles with a fluorosilane coupling agent (FAS). Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), a particle size analyzer, a contact angle instrument (CA), X-ray photoelectron spectroscopy (XPS), a universal materials tester and an Incucyte™ Zoom system were used to characterize the morphology, molecular interactions, superhydrophobic performance, and cytotoxicity. Results show that GSF modified by silica nanoparticles with a particle size of 303 nm has the largest contact angle (158.6°). At the same time, the contact angle is still more than 150° after 48 hours of infiltration in water. These results indicate that GSF has strong long-term water resistance. In addition, GSF has good mechanical strength, durability and nontoxicity. Therefore, such a durable, robust and superhydrophobic film has good potential applications in various functional biomedical aspects.
作为一种可降解的天然生物材料，明胶具有良好的生物相容性和无毒特性，但明胶易溶于水，这限制了其应用。为了解决这一棘手的缺陷，通过先将二氧化硅纳米颗粒接枝到明胶膜上，然后用氟硅烷偶联剂（FAS）对二氧化硅纳米颗粒进行改性，制备了超疏水明胶膜（GSF）。采用傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、粒度分析仪、接触角仪（CA）、X射线光电子能谱（XPS）、万能材料试验机和Incucyte™ Zoom系统对其形态、分子相互作用、超疏水性能和细胞毒性进行了表征。结果表明，粒径为303 nm的二氧化硅纳米颗粒改性的GSF具有最大的接触角（158.6°）。同时，在水中浸润48小时后，接触角仍大于150°。这些结果表明GSF具有很强的长期耐水性。此外，GSF具有良好的机械强度、耐久性和无毒特性。因此，这种耐用、坚固且超疏水的薄膜在各种功能性生物医学方面具有良好的潜在应用前景。
