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一种用于快速检测活细胞中过氧化氢的新型比率荧光探针。

A novel ratiometric fluorescent probe for rapid detection of hydrogen peroxide in living cells.

作者信息

Hu Linan, Liu Jiayi, Zhang Jie, Zhang Hailiang, Xu Pengfei, Chen Zhu, Xiao Enhua

机构信息

Departments of Radiology, The Second Xiangya Hospital, Central South University Changsha Hunan 410011 P. R. China.

Departments of Radiology, Zhuzhou Central Hospital Zhuzhou Hunan 412000 P. R. China.

出版信息

RSC Adv. 2019 Dec 2;9(67):39532-39535. doi: 10.1039/c9ra07517h. eCollection 2019 Nov 27.

DOI:10.1039/c9ra07517h
PMID:35540638
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9076112/
Abstract

In this work, we present a new ratiometric fluorescent probe JNY-1 for rapid and convenient detection of HO. The probe could selectively and sensitively respond to HO within 10 min. In addition, this probe was successfully applied for monitoring and imaging of HO in liver cancer HepG2 cells under physiological conditions.

摘要

在本研究中，我们提出了一种用于快速便捷检测HO的新型比率荧光探针JNY-1。该探针能够在10分钟内对HO进行选择性和灵敏的响应。此外，该探针已成功应用于在生理条件下对肝癌HepG2细胞中的HO进行监测和成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/8f6a769b5a81/c9ra07517h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/c78f210c0740/c9ra07517h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/721ab3c99695/c9ra07517h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/0b291ad5c7e5/c9ra07517h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/fdcf46fd48d5/c9ra07517h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/11743d4c6b71/c9ra07517h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/281fde409f0b/c9ra07517h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/8f6a769b5a81/c9ra07517h-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/c78f210c0740/c9ra07517h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/721ab3c99695/c9ra07517h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/0b291ad5c7e5/c9ra07517h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/fdcf46fd48d5/c9ra07517h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/11743d4c6b71/c9ra07517h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/281fde409f0b/c9ra07517h-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2de3/9076112/8f6a769b5a81/c9ra07517h-f6.jpg

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本文引用的文献

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A General Method To Increase Stokes Shift by Introducing Alternating Vibronic Structures.引入交替振子结构以增大斯托克斯位移的通用方法。
J Am Chem Soc. 2018 Jun 20;140(24):7716-7722. doi: 10.1021/jacs.8b04404. Epub 2018 Jun 8.
2
Evaluating Drug-Induced Liver Injury and Its Remission via Discrimination and Imaging of HClO and HS with a Two-Photon Fluorescent Probe.基于双光子荧光探针对 HClO 和 HS 的分辨和成像来评估药物性肝损伤及其缓解。
Anal Chem. 2018 Jun 19;90(12):7510-7516. doi: 10.1021/acs.analchem.8b01106. Epub 2018 May 30.
3
Versatile Histochemical Approach to Detection of Hydrogen Peroxide in Cells and Tissues Based on Puromycin Staining.
基于嘌呤霉素染色的细胞和组织中过氧化氢检测的多功能组织化学方法。
J Am Chem Soc. 2018 May 16;140(19):6109-6121. doi: 10.1021/jacs.8b02279. Epub 2018 May 3.
4
Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation.糖尿病与阿尔茨海默病中的氧化毒性：ROS/RNS 生成背后的机制。
J Biomed Sci. 2017 Sep 19;24(1):76. doi: 10.1186/s12929-017-0379-z.
5
Wide-Acidity-Range pH Fluorescence Probes for Evaluation of Acidification in Mitochondria and Digestive Tract Mucosa.宽酸度范围 pH 荧光探针用于评估线粒体和消化道黏膜的酸化。
Anal Chem. 2017 Aug 15;89(16):8509-8516. doi: 10.1021/acs.analchem.7b02164. Epub 2017 Jul 24.
6
Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species.近年来用于检测活性氧和氮物种的荧光、发光和比色探针的发展进展。
Chem Soc Rev. 2016 May 21;45(10):2976-3016. doi: 10.1039/c6cs00192k. Epub 2016 Apr 19.
7
Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals.活性氧（ROS）与癌症：抗氧化营养保健品的作用。
Cancer Lett. 2017 Feb 28;387:95-105. doi: 10.1016/j.canlet.2016.03.042. Epub 2016 Mar 29.
8
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Org Biomol Chem. 2015 Apr 14;13(14):4143-8. doi: 10.1039/c4ob02267j. Epub 2014 Dec 17.