Kalidasan V, Liu X L, Li Y, Sugumaran P J, Liu A H, Ren L, Ding J
Department of Materials Science & Engineering, Faculty of Engineering, National University of Singapore 7 Engineering Drive 1 117574 Singapore
Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology Beijing 100190 People's Republic of China
RSC Adv. 2018 Jan 4;8(3):1443-1450. doi: 10.1039/c7ra11472a. eCollection 2018 Jan 2.
In this paper, the effect and contribution of physiological components like ions and proteins under an applied alternating magnetic field (AMF) towards heat dissipation of superparamagnetic iron oxide nanoparticles (SPIONs) are discussed. Our results have shown that under an applied AMF, magnetic hyperthermia efficiency could be significantly enhanced if SPIONs were suspended in 1× phosphate buffered saline (PBS) compared to a suspension in de-ionized (DI) water. However, no heat enhancement was found when SPIONs were suspended in blood which is an amalgamation of physiological ions and proteins. Closer investigations have revealed that the presence of physiological ions can contribute positively to heating efficiency, and the heating efficiency increases with concentration of ions, ionic mass and solubility. However, the heating efficiency of ions can be suppressed to an insignificant level (comparable with measurement error), in the presence of physiological proteins in 1×PBS. Our electrochemical studies also showed that ionic mobility can be reduced significantly if proteins were present in the solution, thus retarding the heating efficiency.
本文讨论了在施加交变磁场（AMF）的情况下，离子和蛋白质等生理成分对超顺磁性氧化铁纳米颗粒（SPIONs）散热的影响和贡献。我们的结果表明，在施加AMF的情况下，与悬浮在去离子（DI）水中相比，如果将SPIONs悬浮在1×磷酸盐缓冲盐水（PBS）中，磁热疗效率可显著提高。然而，当SPIONs悬浮在由生理离子和蛋白质混合而成的血液中时，未发现热增强现象。进一步研究表明，生理离子的存在可对加热效率产生积极贡献，且加热效率随离子浓度、离子质量和溶解度的增加而提高。然而，在1×PBS中存在生理蛋白质的情况下，离子的加热效率可被抑制到微不足道的水平（与测量误差相当）。我们的电化学研究还表明，如果溶液中存在蛋白质，离子迁移率会显著降低，从而阻碍加热效率。
