用于活海马组织切片大气压质谱成像的纳米材料与连续波激光高效解吸
Nanomaterials and continuous wave laser-based efficient desorption for atmospheric pressure mass spectrometric imaging of live hippocampal tissue slices.
作者信息
Kim Jae Young, Seo Eun Seok, Lim Hee Jin, Kim Hyunmin, Park Ji-Won, Shin Hyeon Ho, Lim Dong-Kwon, Moon Dae Won
机构信息
Department of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu Republic of Korea
Companion Diagnostics and Medical Technology Research Group, Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu Republic of Korea.
出版信息
RSC Adv. 2018 Feb 20;8(15):8021-8025. doi: 10.1039/c8ra00038g. eCollection 2018 Feb 19.
Micrometer-resolution mass spectrometric imaging of live hippocampal tissue is achieved with a highly efficient desorption of biomolecules using a 532 nm continuous wave laser and gold nanoparticles or graphene oxide as an energy transporter, which enables clear identification of the distributions of monoacylglycerol, adenine, cholesterol, sphingosine and ceramide.
利用532纳米连续波激光以及金纳米颗粒或氧化石墨烯作为能量传输体，对生物分子进行高效解吸，实现了对活海马组织的微米级分辨率质谱成像，这使得能够清晰识别单酰甘油、腺嘌呤、胆固醇、鞘氨醇和神经酰胺的分布。
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