Lebceuf D, Rousset D, Cacault J A, Engelman P
Rev Fr Gynecol Obstet. 1987 Jan;82(1):9-15.
The efficacy and safety of two antibiotic combination (clindamycin + gentamycin [C + G] versus metronidazole + gentamycin [M + G]) have been compared in 45 in-patients suffering from pelvic inflammatory disease in a clinical prospective randomized trial. The rates of clinical and bacteriological recovery reached respectively 85.7% and 71.4% for C + G group compared to 83.3% and 78.6% for M + G group (no significant differences). Side effects (vomiting, gastralgia and vaginal mycosis) developed in four occasions in each group. The most frequently isolated organisms were chlamydiae, E. coli and Neisseria gonorrheae (around 50% of overall isolated organisms). Due to the lack of significant differences between the two antibiotic combinations, the final choice will depend on potential risks generated by these products.
在一项临床前瞻性随机试验中，对45例盆腔炎住院患者比较了两种抗生素联合用药（克林霉素+庆大霉素[C+G]与甲硝唑+庆大霉素[M+G]）的疗效和安全性。C+G组的临床和细菌学恢复率分别达到85.7%和71.4%，而M+G组为83.3%和78.6%（无显著差异）。每组均有4例出现副作用（呕吐、胃痛和阴道霉菌病）。最常分离出的病原体为衣原体、大肠杆菌和淋病奈瑟菌（约占分离出的病原体总数的50%）。由于两种抗生素联合用药之间缺乏显著差异，最终的选择将取决于这些产品产生的潜在风险。
