荖叶多酚的抗缺氧药理作用。
Anti-hypoxic pharmacological effects of betelnut polyphenols.
机构信息
Department of Pharmacy, 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou 730050.
School of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou 730000.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Apr 28;47(4):512-520. doi: 10.11817/j.issn.1672-7347.2022.210582.
Abstract
L. medicinal materials and their preparations are widely used in clinical practice. Betelnut polyphenol is one of the main chemical components with antioxidant, anti-inflammatory, and antibacterial effects. With continuous increase of high altitude activities, tissue oxidative damage caused by high altitude hypoxia seriously affects the ability to work, and the studies on anti-hypoxia drugs are particularly important. Recent studies have shown that betelnut polyphenols have protective effects on oxidative stress injury caused by hypoxia via improving blood gas index of hypoxic organism, increasing superoxide dismutase glutathione catalase activity, and scavenging excessive free radicals. The effects of betelnut polyphenols against hypoxia and oxidative damage protection suggest that betelnut polyphenols can be used as potential anti-hypoxia drugs and posses clinical prospects.
摘要
荖叶多酚是具有抗氧化、抗炎、抗菌作用的主要化学成分之一。随着高海拔活动的不断增加，高海拔缺氧引起的组织氧化损伤严重影响工作能力，抗缺氧药物的研究尤为重要。最近的研究表明，荖叶多酚通过改善低氧机体的血气指标、增加超氧化物歧化酶谷胱甘肽过氧化物酶的活性、清除过多的自由基，对缺氧引起的氧化应激损伤具有保护作用。荖叶多酚的抗缺氧和氧化损伤保护作用提示荖叶多酚可用作潜在的抗缺氧药物，具有临床应用前景。
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