Obstetrics and Gynecology, Odawara Municipal Hospital, Odawara, Kanagawa, Japan.
Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
J Int Med Res. 2022 May;50(5):3000605221097488. doi: 10.1177/03000605221097488.
This study was conducted to evaluate the status and role of cervical cytology affected by human papillomavirus infection and other infectious diseases screened during routine prenatal checkups.
We retrospectively examined medical records containing the screening results for infectious diseases and cervical cancer in women who delivered neonates in our hospital from 2014 to 2017.
Among 3393 deliveries, 18.8% of women underwent a regular cervical cancer screening within 1 year of becoming pregnant, and 2641 women underwent a cervical cytology screening during this pregnancy. The cytological diagnostic results showed that 2562 women (97.0%) were negative for intraepithelial lesions or malignancy, whereas 79 (3.0%) had abnormal results. Of those with abnormal cytology results, 70 had abnormal cytology that was newly detected in this pregnancy, and 42 had grade ≥1 cervical intraepithelial neoplasia lesions. Spatulas were the most frequently used cytological sampling instruments, followed by cotton swabs. Cervical cytology revealed no major adverse reactions during these pregnancies.
Our results confirm the importance of screening for infectious diseases during pregnancy. Only 20% of the women underwent a regular pre-pregnancy cervical cytology screening. Cervical cytology screening during pregnancy may currently be playing a crucial role in preventing cervical cancer in Japan.
本研究旨在评估人乳头瘤病毒感染及其他传染病对常规产前检查中宫颈细胞学的影响。
我们回顾性分析了 2014 年至 2017 年在我院分娩的妇女的传染病和宫颈癌筛查的医疗记录。
在 3393 例分娩中，18.8%的孕妇在怀孕前 1 年内进行了常规宫颈癌筛查，2641 例孕妇在此次妊娠中进行了宫颈细胞学筛查。细胞学诊断结果显示，2562 例（97.0%）患者上皮内病变或恶性肿瘤阴性，79 例（3.0%）结果异常。异常细胞学结果中，70 例为此次妊娠新发现的异常细胞学，42 例为宫颈上皮内瘤变 1 级及以上病变。最常使用的细胞学采样器械为宫颈刷，其次为棉签。这些妊娠期间宫颈细胞学检查未发生重大不良反应。
我们的结果证实了妊娠期间筛查传染病的重要性。只有 20%的孕妇进行了常规孕前宫颈细胞学筛查。目前，妊娠期间的宫颈细胞学筛查可能在预防日本宫颈癌方面发挥着关键作用。
