Dubrow Geoffrey A, Pawar Rahul S, Srigley Cynthia, Fong Sam Jennifer, Talavera Christian, Parker Christine H, Noonan Gregory O
Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5001 Campus Drive, College Park, MD, 20740, United States.
J Food Compost Anal. 2021 Jan 7;97. doi: 10.1016/j.jfca.2020.103800. Epub 2021 Apr 1.
The 2018 Agricultural Improvement Act removed hemp from Schedule I control, creating a market for hemp products, including cannabidiol-containing products. Due to the market's rapid growth, little is known about the presence and concentration of cannabinoids in commercial products. Herein, 11 cannabinoids were quantified using liquid chromatography with diode-array detection in a non-representative sampling of 147 products labeled as containing hemp or cannabidiol. A subset of 133 products were analyzed for toxic elements using inductively coupled plasma-mass spectrometry. Cannabinoid content ranged from < LOD - 143 mg/serving, with a median of 16.7 mg/serving. Fewer than half of products surveyed contained cannabidiol concentrations within 20 % of their label declarations. The estimated exposure to lead was below the Interim Reference Level of 12.5 μg/day Pb for women of childbearing age, and most products presented concentrations of Δ-tetrahydrocannabinol below LOQ. These findings emphasize the need for further testing and representative investigation of the cannabidiol marketplace.
2018年《农业改进法案》将大麻从附表一的管制中移除，为大麻产品创造了市场，包括含大麻二酚的产品。由于市场的快速增长，对于商业产品中大麻素的存在情况和浓度了解甚少。在此，在对147种标明含有大麻或大麻二酚的产品进行的非代表性抽样中，使用带二极管阵列检测的液相色谱法定量了11种大麻素。使用电感耦合等离子体质谱法对其中133种产品的子集进行了有毒元素分析。大麻素含量范围为<检测限-143毫克/份，中位数为16.7毫克/份。接受调查的产品中，不到一半的产品所含大麻二酚浓度在其标签声明的20%范围内。估计育龄妇女铅暴露低于12.5微克/天铅的临时参考水平，且大多数产品中Δ-四氢大麻酚的浓度低于定量限。这些发现强调了对大麻二酚市场进行进一步检测和代表性调查的必要性。
