Zhou Chuankai
Buck Institute for Research on Aging, Novato, CA, United States.
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States.
Front Cell Dev Biol. 2022 Apr 25;10:896305. doi: 10.3389/fcell.2022.896305. eCollection 2022.
A major recent advance in cell biology is the mechanistic and kinetic understanding of biogenesis of many membrane-less condensates. As membrane-less condensates and membrane-bound organelles are two major approaches used by the eukaryotic cells to organize cellular contents, it is not surprising that these membrane-less condensates interact with the membrane-bound organelles and are dynamically regulated by the cellular signaling, metabolic states, and proteostasis network. In this review, I will discuss recent progress in the biogenesis of membrane-less condensates and their connections with well-studied membrane-bound organelles. Future work will reveal the molecular and functional connectome among different condensates and membrane-bound organelles.
细胞生物学领域最近的一项重大进展是对许多无膜凝聚物生物发生的机制和动力学有了深入了解。由于无膜凝聚物和膜结合细胞器是真核细胞用于组织细胞内容物的两种主要方式，因此这些无膜凝聚物与膜结合细胞器相互作用，并受到细胞信号传导、代谢状态和蛋白质稳态网络的动态调节也就不足为奇了。在这篇综述中，我将讨论无膜凝聚物生物发生的最新进展及其与研究充分的膜结合细胞器的联系。未来的工作将揭示不同凝聚物和膜结合细胞器之间的分子和功能连接组。
