Goldstein I, Reece E A, Pilu G, Bovicelli L, Hobbins J C
Am J Obstet Gynecol. 1987 May;156(5):1065-9. doi: 10.1016/0002-9378(87)90111-6.
A prospective study of ultrasonography was conducted in 371 normal pregnant women, with gestational ages ranging from 13 weeks to 40 weeks. Several biometric measurements were obtained including the transverse cerebellar diameter, the biparietal diameter, the occipitofrontal diameter, and the calculated head circumference. Curvilinear relationships were found between the transverse diameter of the cerebellum (measured in millimeters), and the gestational age (R2 = 0.948; P = 0.001), the biparietal diameter (R2 = 0.956; P = 0.0001), and the head circumference (R2 = 0.969; P = 0.0001). A nomogram of cerebellar measurements estimating gestational age and predicting the biparietal diameter and head circumference was generated. Throughout pregnancy the establishment of normative cerebellar measurements allows for the estimation of gestational age that is independent of the shape of the fetal head and offers potential for evaluation of abnormal fetal growth and anomalous development of the central nervous system.
对371名孕周在13周至40周的正常孕妇进行了超声检查的前瞻性研究。获得了多项生物测量数据，包括小脑横径、双顶径、枕额径和计算得出的头围。发现小脑横径（以毫米为单位）与孕周（R2 = 0.948；P = 0.001）、双顶径（R2 = 0.956；P = 0.0001）和头围（R2 = 0.969；P = 0.0001）之间呈曲线关系。生成了一张估计孕周以及预测双顶径和头围的小脑测量列线图。在整个孕期，建立正常的小脑测量值有助于估计孕周，这与胎儿头部形状无关，并为评估胎儿生长异常和中枢神经系统发育异常提供了可能。
