• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过微流控纺丝制备的用于慢性伤口敷料的高吸水性海藻酸钙纤维支架。

High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings.

作者信息

Cai Jie, Chen Xiaojing, Wang Xiaojing, Tan Yulu, Ye Dongdong, Jia Yongtang, Liu Peifeng, Yu Hui

机构信息

The Engineering Technology Research Center for Functional Textiles in Higher Education of Guangdong Province, College of Textile Materials and Engineering, Wuyi University Jiangmen 529020 China

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200032 China.

出版信息

RSC Adv. 2018 Nov 26;8(69):39463-39469. doi: 10.1039/c8ra06922k. eCollection 2018 Nov 23.

DOI:10.1039/c8ra06922k
PMID:35558052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9090719/
Abstract

More and more water-absorbing wound dressings have been studied since moist wound-healing treatment can effectively promote the healing of wounds. In this work, we introduce a novel method to produce improved wound dressings with high-water-absorbance. A high-water-absorbing calcium alginate (Ca-Alg) fibrous scaffold was fabricated simply by microfluidic spinning and centrifugal reprocessing. The structure and physical properties of the scaffold were characterized, and its water-absorbing, cytotoxicity properties and other applicability to wound dressings were comprehensively evaluated. Our results indicate that this material possesses high water-absorbing properties, is biocompatible, and has a 3D structure that mimics the extracellular matrix, while Ca-Alg fibers loaded with silver nanoparticles (AgNPs) exhibit broad-spectrum antibacterial activities; these properties meet the requirements for promoting the healing of chronic wounds and are widely applicable to wound dressings.

摘要

由于湿性伤口愈合疗法能够有效促进伤口愈合，越来越多的吸水性伤口敷料得到了研究。在这项工作中，我们介绍了一种生产具有高吸水性的改良伤口敷料的新方法。通过微流控纺丝和离心后处理简单地制备了一种高吸水性海藻酸钙（Ca-Alg）纤维支架。对该支架的结构和物理性能进行了表征，并对其吸水性、细胞毒性性能以及对伤口敷料的其他适用性进行了综合评估。我们的结果表明，这种材料具有高吸水性、生物相容性，并且具有模拟细胞外基质的三维结构，而负载银纳米颗粒（AgNPs）的Ca-Alg纤维表现出广谱抗菌活性；这些特性满足促进慢性伤口愈合的要求，并且广泛适用于伤口敷料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/928ff0af8aa4/c8ra06922k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/b497c076279a/c8ra06922k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/428afabecf9c/c8ra06922k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/4801597a4526/c8ra06922k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/51121f7b3c40/c8ra06922k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/06a5bddb6996/c8ra06922k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/d6dacf2e084a/c8ra06922k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/700e76f15c2a/c8ra06922k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/943152525bb2/c8ra06922k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/928ff0af8aa4/c8ra06922k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/b497c076279a/c8ra06922k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/428afabecf9c/c8ra06922k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/4801597a4526/c8ra06922k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/51121f7b3c40/c8ra06922k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/06a5bddb6996/c8ra06922k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/d6dacf2e084a/c8ra06922k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/700e76f15c2a/c8ra06922k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/943152525bb2/c8ra06922k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8479/9090719/928ff0af8aa4/c8ra06922k-f9.jpg

相似文献

1
High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings.通过微流控纺丝制备的用于慢性伤口敷料的高吸水性海藻酸钙纤维支架。
RSC Adv. 2018 Nov 26;8(69):39463-39469. doi: 10.1039/c8ra06922k. eCollection 2018 Nov 23.
2
In situ reduction of silver nanoparticles by sodium alginate to obtain silver-loaded composite wound dressing with enhanced mechanical and antimicrobial property.通过海藻酸钠原位还原制备载银复合伤口敷料，提高其机械性能和抗菌性能。
Int J Biol Macromol. 2020 Apr 1;148:501-509. doi: 10.1016/j.ijbiomac.2020.01.156. Epub 2020 Jan 17.
3
Scar free healing of full thickness diabetic wounds: A unique combination of silver nanoparticles as antimicrobial agent, calcium alginate nanoparticles as hemostatic agent, fresh blood as nutrient/growth factor supplier and chitosan as base matrix.无疤痕治愈全层糖尿病创面：银纳米粒子作为抗菌剂、海藻酸钠纳米粒子作为止血剂、新鲜血液作为营养/生长因子供应源以及壳聚糖作为基质的独特组合。
Int J Biol Macromol. 2021 May 1;178:41-52. doi: 10.1016/j.ijbiomac.2021.02.133. Epub 2021 Feb 20.
4
Improving anti-hemolytic, antibacterial and wound healing properties of alginate fibrous wound dressings by exchanging counter-cation for infected full-thickness skin wounds.通过用反离子交换感染的全层皮肤伤口来提高藻酸盐纤维伤口敷料的抗溶血、抗菌和伤口愈合性能。
Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110321. doi: 10.1016/j.msec.2019.110321. Epub 2019 Oct 22.
5
Modulation of NK cell activation by exogenous calcium from alginate dressings .藻酸盐敷料中外源钙对 NK 细胞活化的调节作用。
Front Immunol. 2023 Apr 6;14:1141047. doi: 10.3389/fimmu.2023.1141047. eCollection 2023.
6
Cobalt-mediated multi-functional dressings promote bacteria-infected wound healing.钴介导的多功能敷料促进细菌感染性伤口愈合。
Acta Biomater. 2019 Mar 1;86:465-479. doi: 10.1016/j.actbio.2018.12.048. Epub 2018 Dec 30.
7
Topical silver for infected wounds.局部用银治疗感染性创面。
J Athl Train. 2009 Sep-Oct;44(5):531-3. doi: 10.4085/1062-6050-44.5.531.
8
Alginate membranes loaded with hyaluronic acid and silver nanoparticles to foster tissue healing and to control bacterial contamination of non-healing wounds.载有透明质酸和银纳米粒子的海藻酸盐膜，以促进组织愈合，并控制难愈伤口的细菌污染。
J Mater Sci Mater Med. 2018 Feb 2;29(3):22. doi: 10.1007/s10856-018-6027-7.
9
Microbial alginate dressings show improved binding capacity for pathophysiological factors in chronic wounds compared to commercial alginate dressings of marine origin.与海洋来源的商业藻酸盐敷料相比，微生物藻酸盐敷料对慢性伤口中的病理生理因素显示出更高的结合能力。
J Biomater Appl. 2017 Apr;31(9):1267-1276. doi: 10.1177/0885328217702173. Epub 2017 Mar 29.
10
Alginate-Based Materials Loaded with Nanoparticles in Wound Healing.负载纳米颗粒的藻酸盐基材料在伤口愈合中的应用
Pharmaceutics. 2023 Apr 4;15(4):1142. doi: 10.3390/pharmaceutics15041142.

引用本文的文献

1
Advanced biomaterial strategies for overcoming age-associated wound healing impairments.克服与年龄相关的伤口愈合障碍的先进生物材料策略。
APL Bioeng. 2025 Jun 6;9(2):021501. doi: 10.1063/5.0251889. eCollection 2025 Jun.
2
Functionalised Hybrid Collagen-Elastin for Acellular Cutaneous Substitute Applications.用于无细胞皮肤替代物应用的功能化混合胶原蛋白-弹性蛋白
Polymers (Basel). 2023 Apr 18;15(8):1929. doi: 10.3390/polym15081929.
3
Alginate-Based Materials Loaded with Nanoparticles in Wound Healing.负载纳米颗粒的藻酸盐基材料在伤口愈合中的应用

本文引用的文献

1
Designing electrospun nanofiber mats to promote wound healing - a review.设计用于促进伤口愈合的电纺纳米纤维垫——综述
J Mater Chem B. 2013 Sep 28;1(36):4531-4541. doi: 10.1039/c3tb20795a. Epub 2013 Aug 8.
2
Microfluidic spinning of the fibrous alginate scaffolds for modulation of the degradation profile.用于调节降解曲线的纤维状藻酸盐支架的微流控纺丝。
Tissue Eng Regen Med. 2016 Apr 5;13(2):140-148. doi: 10.1007/s13770-016-9048-7. eCollection 2016 Apr.
3
Large-scale water collection of bioinspired cavity-microfibers.生物启发的腔状微纤维的大规模集水
Pharmaceutics. 2023 Apr 4;15(4):1142. doi: 10.3390/pharmaceutics15041142.
4
Alginate-Based Biomaterials in Tissue Engineering and Regenerative Medicine.基于海藻酸盐的生物材料在组织工程和再生医学中的应用
Mar Drugs. 2023 Mar 18;21(3):189. doi: 10.3390/md21030189.
5
Calcium Alginate Production through Forward Osmosis with Reverse Solute Diffusion and Mechanism Analysis.通过具有反向溶质扩散的正向渗透法生产海藻酸钙及其机理分析
Membranes (Basel). 2023 Feb 8;13(2):207. doi: 10.3390/membranes13020207.
6
Microfluidic Fabrication of Natural Polymer-Based Scaffolds for Tissue Engineering Applications: A Review.用于组织工程应用的天然聚合物基支架的微流体制备：综述
Biomimetics (Basel). 2023 Feb 9;8(1):74. doi: 10.3390/biomimetics8010074.
7
Different Curcumin-Loaded Delivery Systems for Wound Healing Applications: A Comprehensive Review.用于伤口愈合的不同载姜黄素递送系统：综述
Pharmaceutics. 2022 Dec 22;15(1):38. doi: 10.3390/pharmaceutics15010038.
8
Graphene Oxide-alginate Hydrogel for Drawing Water through an Osmotic Membrane.用于通过渗透膜吸水的氧化石墨烯-海藻酸盐水凝胶
ACS Omega. 2022 Oct 18;7(43):38337-38346. doi: 10.1021/acsomega.2c03138. eCollection 2022 Nov 1.
9
Recent Progress in Development of Dressings Used for Diabetic Wounds with Special Emphasis on Scaffolds.近期糖尿病创面敷料的研究进展，特别强调了支架的应用。
Biomed Res Int. 2022 Jul 4;2022:1659338. doi: 10.1155/2022/1659338. eCollection 2022.
10
Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization.电纺纤维及其在药物控释、生物敷料、组织修复和酶固定化中的应用。
RSC Adv. 2019 Aug 15;9(44):25712-25729. doi: 10.1039/c9ra05012d. eCollection 2019 Aug 13.
Nat Commun. 2017 Oct 20;8(1):1080. doi: 10.1038/s41467-017-01157-4.
4
Bioinspired Microfibers with Embedded Perfusable Helical Channels.具有嵌入式可灌注螺旋通道的仿生微纤维。
Adv Mater. 2017 Sep;29(34). doi: 10.1002/adma.201701664. Epub 2017 Jun 22.
5
Simultaneous microfluidic spinning of multiple strands of submicron fiber for the production of free-standing porous membranes for biological application.同时进行多股亚微米纤维的微流控纺丝，以制备用于生物应用的独立式多孔膜。
Biofabrication. 2017 Jun 1;9(2):025026. doi: 10.1088/1758-5090/aa7307.
6
Terbinafine-loaded wound dressing for chronic superficial fungal infections.用于慢性浅表真菌感染的含特比萘芬伤口敷料。
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:130-136. doi: 10.1016/j.msec.2016.12.078. Epub 2016 Dec 18.
7
Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells.氧化锌纳米颗粒的海藻酸钠和阿拉伯胶水凝胶对成纤维细胞具有伤口愈合作用。
Int J Biol Macromol. 2017 Mar;96:185-191. doi: 10.1016/j.ijbiomac.2016.12.009. Epub 2016 Dec 6.
8
Electrospinning versus microfluidic spinning of functional fibers for biomedical applications.静电纺丝与微流控纺丝在生物医学应用中的功能纤维制备。
Biomaterials. 2017 Jan;114:121-143. doi: 10.1016/j.biomaterials.2016.10.040. Epub 2016 Nov 5.
9
Simple Spinning of Heterogeneous Hollow Microfibers on Chip.在芯片上简单纺制异质中空微纤维。
Adv Mater. 2016 Aug;28(31):6649-55. doi: 10.1002/adma.201601504. Epub 2016 May 17.
10
Development and physicochemical characterization of alginate composite film loaded with simvastatin as a potential wound dressing.载有辛伐他汀的海藻酸盐复合膜的制备及理化性质研究——一种有潜力的伤口敷料
Carbohydr Polym. 2016 Feb 10;137:295-304. doi: 10.1016/j.carbpol.2015.10.091. Epub 2015 Nov 2.