Zhu Shuya, Zhang Yinxiao, Wang Jingyi, Zhang Chi, Liu Xinqi
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, National Soybean Processing Industry Technology Innovation Center, School of Food and Health, Beijing Technology and Business University, Beijing 100048, China.
Foods. 2022 Apr 26;11(9):1251. doi: 10.3390/foods11091251.
Soybean protein and peptides have the potential to promote the growth of , but the mechanisms involved are not well understood. The purpose of this study is to investigate differentially expressed genes (DEGs) of () LR08 responding to soybean protein and peptides using transcriptome. The results showed that both digested protein (dpro) and digested peptides (dpep) could enhance a purine biosynthesis pathway which could provide more nucleic acid and ATP for bacteria growth. Moreover, dpep could be used instead of dpro to promote the ABC transporters, especially the genes involved in the transportation of various amino acids. Interestingly, dpro and dpep played opposite roles in modulating DEGs from the and gene families which participate in fatty acid biosynthesis. These not only provide a new direction for developing nitrogen-sourced prebiotics in the food industry but could also help us to understand the fundamental mechanism of the effects of dpro and dpep on their growth and metabolisms and provides relevant evidence for further investigation.
大豆蛋白和肽有促进[具体对象]生长的潜力，但其中涉及的机制尚未完全清楚。本研究的目的是利用转录组研究[具体对象]LR08对大豆蛋白和肽作出反应的差异表达基因（DEGs）。结果表明，消化后的蛋白质（dpro）和消化后的肽（dpep）都能增强嘌呤生物合成途径，该途径可为细菌生长提供更多核酸和ATP。此外，dpep可替代dpro来促进ABC转运蛋白，尤其是参与各种氨基酸运输的基因。有趣的是，dpro和dpep在调节参与脂肪酸生物合成的[具体基因家族1]和[具体基因家族2]基因家族的DEGs方面发挥着相反的作用。这些不仅为食品工业中开发氮源益生元提供了新方向，还能帮助我们理解dpro和dpep对其生长和代谢影响的基本机制，并为进一步研究提供相关证据。
