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部分水解蛋白作为婴儿喂养的蛋白质来源:该用还是不该用?

Partial Hydrolyzed Protein as a Protein Source for Infant Feeding: Do or Don't?

机构信息

KidZ Health Castle, Vrije Universiteit Brussel (VUB), 1090 Brussel, Belgium.

Department of Pediatrics, Nutrition, and Metabolic Diseases, The Children's Memorial Health Institute, 04-730 Warsaw, Poland.

出版信息

Nutrients. 2022 Apr 21;14(9):1720. doi: 10.3390/nu14091720.

DOI:10.3390/nu14091720
PMID:35565688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9103110/
Abstract

Exclusive breastfeeding until the age of six months is the recommended feeding method for all infants. However, this is not possible for every infant. Therefore, a second choice of feeding, as close as possible to the gold standard, is needed. For historical reasons, this has been cow's-milk-based feeding. This paper discusses if this second-choice feeding method should contain intact protein or partially hydrolyzed proteins. The limited data available indicates that mother's milk is relatively rich in bioactive peptides. Whether partially hydrolyzed protein might be a protein source closer to human milk protein content than intact cow's milk needs further research. However, more research on protein and bioactive peptides in mother's milk should be a priority for future scientific development in this field. Results of such research will also provide an answer to the question of which option would be the best second choice for infant feeding if sufficient breast milk is not available.

摘要

纯母乳喂养至六个月大是所有婴儿的推荐喂养方式。然而,并非每个婴儿都能做到这一点。因此,需要一种尽可能接近黄金标准的第二选择喂养方式。由于历史原因,这种喂养方式一直是基于牛奶的。本文讨论了这种第二选择的喂养方法是否应该包含完整的蛋白质或部分水解的蛋白质。现有有限的数据表明,母乳中相对富含生物活性肽。部分水解蛋白是否可能成为一种比完整牛奶更接近人乳蛋白质含量的蛋白质来源,需要进一步研究。然而,对于该领域未来的科学发展,应优先研究母乳中的蛋白质和生物活性肽。如果没有足够的母乳,这些研究的结果也将回答哪种选择是婴儿喂养的最佳第二选择的问题。

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本文引用的文献

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Peptide Characterization and Functional Stability of a Partially Hydrolyzed Whey-Based Formula over Time.随时间推移的部分水解乳基配方的肽特性和功能稳定性。
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Partially Hydrolysed Whey Has Superior Allergy Preventive Capacity Compared to Intact Whey Regardless of Amoxicillin Administration in Brown Norway Rats.部分水解乳清蛋白比完整乳清蛋白具有更好的过敏预防能力,这与给予褐家鼠阿莫西林无关。
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Clin Nutr. 2021 Feb;40(2):358-371. doi: 10.1016/j.clnu.2020.10.025. Epub 2020 Oct 20.
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Use of partially hydrolysed formula in infancy and incidence of eczema, respiratory symptoms or food allergies in toddlers from the ELFE cohort.婴儿时期使用部分水解配方与幼儿特应性皮炎、呼吸道症状或食物过敏的相关性:ELFE 队列研究。
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