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代谢综合征成人的肝脂肪变性分期与体力活动表现的关系:FLIPAN 研究的横断面分析。

Association between Stages of Hepatic Steatosis and Physical Activity Performance in Adults with Metabolic Syndrome: A Cross-Sectional Analysis in FLIPAN Study.

机构信息

Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain.

Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain.

出版信息

Nutrients. 2022 Apr 24;14(9):1790. doi: 10.3390/nu14091790.

DOI:10.3390/nu14091790
PMID:35565758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9105320/
Abstract

BACKGROUND

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease. The best treatment now is a healthy lifestyle with a Mediterranean diet and physical activity (PA).

OBJECTIVE

To assess the association between stages of hepatic steatosis and physical activity performance in adults with metabolic syndrome.

DESIGN

Cross-sectional study in 155 participants (40-60 years old) with MetS, a diagnosis of NAFLD by magnetic resonance imaging and BMI (body mass index) between 27 and 40 kg/m.

METHODS

Stages of hepatic steatosis were assessed and defined according to the percentage of intrahepatic fat contents: stage 0 ≤ 6.4% (control group); stage 1 = 6.4-17.4%; stage 2 ≥ 17.4%. Fitness was assessed through ALPHA-FIT test battery for adults, aerobic capacity by Chester-step test and PA by accelerometry and Minnesota questionnaire.

RESULTS

Participants without NAFLD reported more years of education and major socioeconomic status than participants with NAFLD. A higher percentage of people in the most advanced stage of NAFLD were no smokers and no alcohol consumers. They also had higher stages of steatosis, lower sitting handgrip, standing handgrip, Chester step test values, sleep efficiency, and energy expenditure, and higher intensity of light and moderate physical activity, and self-reported physical activity.

CONCLUSIONS

NAFLD patients showed lower fitness status, aerobic capacity, sleep efficiency and energy expenditure than non-NAFLD participants.

摘要

背景

非酒精性脂肪性肝病(NAFLD)是最常见的肝脏疾病。目前最好的治疗方法是地中海饮食和体育锻炼(PA)的健康生活方式。

目的

评估代谢综合征成人肝脂肪变性分期与体力活动表现之间的关系。

设计

对 155 名(40-60 岁)代谢综合征患者进行横断面研究,通过磁共振成像和 BMI(体重指数)诊断为 NAFLD,BMI 为 27-40kg/m。

方法

评估和定义肝脂肪变性分期,根据肝内脂肪含量的百分比:0 期≤6.4%(对照组);1 期=6.4-17.4%;2 期≥17.4%。通过成人 ALPHA-FIT 测试套件评估体能,通过 Chester 台阶测试评估有氧能力,通过加速度计和明尼苏达州问卷评估 PA。

结果

无 NAFLD 的参与者报告的受教育年限和主要社会经济地位高于有 NAFLD 的参与者。NAFLD 最晚期的人群中,不吸烟者和不饮酒者的比例更高。他们的肝脂肪变性分期也更高,握力、握力、 Chester 台阶测试值、睡眠效率和能量消耗较低,轻至中度体力活动和自我报告的体力活动强度较高。

结论

与非 NAFLD 参与者相比,NAFLD 患者的体能、有氧能力、睡眠效率和能量消耗较低。