Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.
Health Institute of the Balearic Islands (IDISBA), 07120 Palma de Mallorca, Spain.
Nutrients. 2022 Mar 3;14(5):1063. doi: 10.3390/nu14051063.
Background: A lifestyle with regular PA (physical activity) and Mediterranean diet has benefits on NAFLD (non-alcoholic fatty liver disease) and MetS (metabolic syndrome). Objectives: To assess the association between physical activity and NAFLD in adults with MetS. Design: Cross-sectional study in 155 participants (40−60 years old) from Balearic Islands and Navarra (Spain) with diagnosis of NAFLD and MetS, and BMI (body mass index) between 27 and 40 Kg/m2. Methods: PA level was categorized into two groups according to weekly METs (metabolic equivalents of tasks). PA was assessed using a validated Minnesota questionnaire and accelerometers. MetS parameters were assessed by blood collection analysis and NAFLD by abdominal MRI (magnetic resonance imaging). Results: Participants with high PA showed more energy expenditure and expended more calories than ingested (−143.9 Kcal/day; p < 0.001). PA was a risk factor for AST (aspartate aminotransferase) (adjusted OR: 7.26; 95% CI: 1.79−29.40) and a protective factor for ALT (alanine aminotransferase) (adjusted OR: 0.24; 95% CI: 0.12−0.48), GGT (gamma-glutamyl transferase) (adjusted OR: 0.52; 95% CI: 0.29−0.94) and IFC-NMR (intrahepatic fat content by nuclear magnetic resonance) (adjusted OR: 0.26; 95% CI: 0.12−0.56) when sociodemographic confounders were considered. Conclusions: NAFLD patients with high PA showed more positive relationship on MetS parameters and liver profile (ALT, GGT, IFC-NMR) than subjects with low PA, but not for AST. Difference between calories ingested and expended influenced this relationship.
有规律的体育锻炼（PA）和地中海饮食的生活方式对非酒精性脂肪肝（NAFLD）和代谢综合征（MetS）有益。目的：评估成年人代谢综合征（MetS）与非酒精性脂肪肝（NAFLD）之间的体力活动相关性。设计：在来自巴利阿里群岛和纳瓦拉（西班牙）的 155 名患有 NAFLD 和 MetS 且 BMI（体重指数）在 27 至 40 Kg/m2 之间的参与者中进行横断面研究。方法：根据每周代谢当量（METs）将 PA 水平分为两组。使用经过验证的明尼苏达州问卷和加速度计评估 PA。通过血液采集分析评估 MetS 参数，通过腹部 MRI（磁共振成像）评估 NAFLD。结果：高 PA 组的参与者表现出更高的能量消耗和消耗的卡路里多于摄入的卡路里（每天减少 143.9 Kcal；p < 0.001）。PA 是天门冬氨酸氨基转移酶（AST）的危险因素（调整后的 OR：7.26；95%CI：1.79−29.40）和丙氨酸氨基转移酶（ALT）的保护因素（调整后的 OR：0.24；95%CI：0.12−0.48），γ-谷氨酰转移酶（GGT）（调整后的 OR：0.52；95%CI：0.29−0.94）和核磁共振（NMR）肝内脂肪含量（IFC-NMR）（调整后的 OR：0.26；95%CI：0.12−0.56），当考虑到社会人口统计学混杂因素时。结论：与低 PA 组相比，高 PA 的 NAFLD 患者在 MetS 参数和肝脏谱（ALT、GGT、IFC-NMR）方面表现出更积极的关系，但 AST 除外。摄入的卡路里与消耗的卡路里之间的差异影响了这种关系。
