Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IDISBA & CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038), 07122 Palma de Mallorca, Spain.
Nutrients. 2021 Dec 23;14(1):49. doi: 10.3390/nu14010049.
Non-alcoholic fatty liver disease (NAFLD) is an excessive accumulation of fat in the liver without alcohol abuse. It is linked to metabolic syndrome (MetS) and no pharmacological treatment exists. This systematic review aims to assess evidence about the effect of Mediterranean lifestyle on the prevention and reversion of NAFLD.
A systematic literature search was performed in MEDLINE via Pubmed. MeSH terms used were: non-alcoholic fatty liver disease [MeSH Major Topic] AND metabolic syndrome [MeSH Term] AND (Diet, Mediterranean [MeSH Term]) OR (Exercise [MeSH Term]). (PROSPERO ID: 2021 CRD42021289495).
Thirteen articles were selected and divided into two categories (four focused on Mediterranean diet and NAFLD and nine focused on Mediterranean diet, physical activity, and NAFLD). Information of clinical endpoints was based on NAFLD, as well as MetS, body mass index, fasting glycemia, obesity, cholesterol, triglycerides, transaminases, albuminuria, and hepatic steatosis, among others. All studies found beneficial associations between the clinical parameters of NAFLD/MetS and following a Mediterranean diet and regular physical activity.
An effective treatment that prevents, and even reverses, NAFLD is to adapt lifestyle to the Mediterranean one, based on a Mediterranean diet and regular physical activity.
非酒精性脂肪性肝病（NAFLD）是指肝脏中脂肪的过度积累，而没有酒精滥用。它与代谢综合征（MetS）有关，目前尚无药物治疗方法。本系统评价旨在评估地中海生活方式对预防和逆转非酒精性脂肪性肝病的效果的证据。
通过 Pubmed 在 MEDLINE 上进行了系统的文献检索。使用的 MeSH 术语是：非酒精性脂肪性肝病[MeSH 主要主题]和代谢综合征[MeSH 术语]和（饮食，地中海[MeSH 术语]）或（运动[MeSH 术语]）。（PROSPERO ID：2021 CRD42021289495）。
选择了 13 篇文章，并分为两类（4 篇专注于地中海饮食和非酒精性脂肪性肝病，9 篇专注于地中海饮食、体育活动和非酒精性脂肪性肝病）。临床终点信息基于非酒精性脂肪性肝病，以及代谢综合征、体重指数、空腹血糖、肥胖、胆固醇、甘油三酯、转氨酶、白蛋白尿和肝脂肪变性等。所有研究都发现地中海饮食和定期体育活动与非酒精性脂肪性肝病/代谢综合征的临床参数之间存在有益的关联。
预防甚至逆转非酒精性脂肪性肝病的有效治疗方法是将生活方式调整为地中海式，基于地中海饮食和定期体育活动。
