Research Division of Food Functionality, Korea Food Research Institute, Wanju 55365, Korea.
Central Research Institute, MEDIOGEN Co., Ltd., Jecheon 27159, Korea.
Nutrients. 2022 May 7;14(9):1965. doi: 10.3390/nu14091965.
Diet-induced obesity is one of the major causes of the development of metabolic disorders such as insulin resistance and nonalcoholic fatty liver disease (NAFLD). Recently, specific probiotic strains have been found to improve the symptoms of NAFLD. We examined the effects of ssp. MG741 (MG741) on NAFLD and weight gain, using a mouse model of high-fat-diet (HFD)-induced obesity. HFD-fed mice were supplemented daily with MG741. After 12 weeks, MG741-administered mice exhibited reduced fat deposition, and serum metabolic alterations, including fasting hyperinsulinemia, were modulated. In addition, MG741 regulated Acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), sterol regulatory element-binding protein 1 (SREBP-1), and carbohydrate-responsive element-binding protein (ChREBP) expression and lipid accumulation in the liver, thereby reducing the hepatic steatosis score. To determine whether the effects of MG741 were related to improvements in gut health, MG741 improved the HFD-induced deterioration in gut permeability by reducing toxic substances and inflammatory cytokine expression, and upregulating tight junctions. These results collectively demonstrate that the oral administration of MG741 could prevent NAFLD and obesity, thereby improving metabolic health.
饮食诱导的肥胖是代谢紊乱发展的主要原因之一，如胰岛素抵抗和非酒精性脂肪性肝病（NAFLD）。最近，发现特定的益生菌菌株可以改善 NAFLD 的症状。我们使用高脂肪饮食（HFD）诱导肥胖的小鼠模型研究了 ssp. MG741（MG741）对 NAFLD 和体重增加的影响。HFD 喂养的小鼠每天补充 MG741。12 周后，MG741 给药组小鼠脂肪沉积减少，血清代谢改变，包括空腹高胰岛素血症得到调节。此外，MG741 调节乙酰辅酶 A 羧化酶（ACC）、脂肪酸合酶（FAS）、固醇调节元件结合蛋白 1（SREBP-1）和碳水化合物反应元件结合蛋白（ChREBP）的表达和肝脏中的脂质积累，从而降低肝脂肪变性评分。为了确定 MG741 的作用是否与改善肠道健康有关，MG741 通过减少毒性物质和炎性细胞因子的表达以及上调紧密连接来改善 HFD 诱导的肠道通透性恶化。这些结果共同表明，口服 MG741 可以预防 NAFLD 和肥胖，从而改善代谢健康。
