National Institute of Food Science and Technology, University of Agriculture, Faisalabad 38000, Pakistan.
College of Food Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Molecules. 2022 Apr 25;27(9):2760. doi: 10.3390/molecules27092760.
Thrombocytopenia is a clinical manifestation that refers to the low platelet count, i.e., <150 × 103/μL, of blood, resulting in imbalanced hemostasis, which leads to several fatal complications. The causative factors vary greatly, but, as a consequence, they interfere with platelet production and promote destruction, leading to death. Carica papaya leaf has unique therapeutic and medicinal characteristics against thrombocytopenia, and this is supported by scientific studies. Secondary metabolites and minerals in the leaf, such as carpaine and quercetin, promote platelet production, inhibit platelet destruction, and maintain platelet membrane through gene expression activity and the ceasing of viral proteases, respectively. This review explores the scientific studies that support the role of papaya leaf in the form of juice, extract, or powder against thrombocytopenia through animal modeling and clinical trials. Phytochemical profiles of C. papaya leaf revealed the presence of flavonoids, alkaloids, phenols, cardiac glycosides, tannins, terpenes, and saponins, which impart therapeutic potential to the leaf. The therapeutic benefits of the leaf include immunomodulatory, antiviral, antidiabetic, anticancer, antimalarial, antiangiogenic, antibacterial, and antioxidant activities. Several conducted scientific research studies have proved the efficacy of C. papaya leaf against thrombocytopenia, expanding the implication of natural sources to eradicate numerous ailments.
血小板减少症是一种临床表现，指的是血液中血小板计数低，即 <150×103/μL，导致止血失衡，从而导致多种致命并发症。其致病因素差异很大，但都会干扰血小板的产生并促进其破坏，导致死亡。木瓜叶对血小板减少症具有独特的治疗和药用特性，这得到了科学研究的支持。叶片中的次生代谢物和矿物质，如卡巴因和槲皮素，通过基因表达活性和停止病毒蛋白酶，分别促进血小板生成、抑制血小板破坏和维持血小板膜。本综述探讨了通过动物模型和临床试验，以果汁、提取物或粉末形式的木瓜叶对抗血小板减少症的科学研究，这些研究支持木瓜叶的作用。番木瓜叶的植物化学特征表明存在类黄酮、生物碱、酚类、强心苷、单宁、萜类化合物和皂苷，这赋予了叶片治疗潜力。叶片的治疗益处包括免疫调节、抗病毒、抗糖尿病、抗癌、抗疟疾、抗血管生成、抗菌和抗氧化活性。多项已进行的科学研究证明了番木瓜叶对血小板减少症的疗效，扩大了天然来源消除多种疾病的影响。
