黑桤木（L.）橡实的乙醇和水提取物的化学特性及其抑菌、抗真菌和抗肿瘤特性。
Chemical Characteristics of Ethanol and Water Extracts of Black Alder ( L.) Acorns and Their Antibacterial, Anti-Fungal and Antitumor Properties.
机构信息
Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland.
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 R. Weigla Street, 53-114 Wroclaw, Poland.
出版信息
Molecules. 2022 Apr 28;27(9):2804. doi: 10.3390/molecules27092804.
The aim of this study was to identify polyphenolic compounds contained in ethanol and water extracts of black alder ( L.) acorns and evaluate their anti-cancer and antimicrobial effects. The significant anti-cancer potential on the human skin epidermoid carcinoma cell line A431 and the human epithelial cell line A549 derived from lung carcinoma tissue was observed. Aqueous and ethanolic extracts of alder acorns inhibited the growth of mainly Gram-positive microorganisms (, , ) and yeast-like fungi (, ), as well as Gram-negative (, , , ) strains. The identification of polyphenols was carried out using an ACQUITY UPLC-PDA-MS system. The extracts were composed of 29 compounds belonging to phenolic acids, flavonols, ellagitannins and ellagic acid derivatives. Ellagitannins were identified as the predominant phenolics in ethanol and aqueous extract (2171.90 and 1593.13 mg/100 g DM, respectively) The results may explain the use of extracts in folk medicine.
本研究旨在鉴定黑桤木（L.）橡实的乙醇和水提取物中所含的多酚化合物，并评估其抗癌和抗菌作用。观察到对人皮肤表皮癌细胞系 A431 和源自肺癌组织的人上皮细胞系 A549 具有显著的抗癌潜力。水提物和醇提物抑制了主要革兰氏阳性微生物（，，）和酵母样真菌（，）以及革兰氏阴性菌（，，，）的生长。多酚的鉴定使用 ACQUITY UPLC-PDA-MS 系统进行。提取物由 29 种化合物组成，属于酚酸、类黄酮、鞣花单宁和鞣花酸衍生物。鞣花单宁被鉴定为乙醇和水提取物中的主要多酚（分别为 2171.90 和 1593.13 mg/100 g DM）。这些结果可以解释民间医学中使用提取物的原因。
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