Alruwaili Nabil K, Ahmad Naveed, Alzarea Abdulaziz I, Alomar Fadhel A, Alquraini Ali, Akhtar Sultan, Shahari Muhammad Syafiq Bin, Zafar Ameeduzzafar, Elmowafy Mohammed, Elkomy Mohammed H, Dolzhenko Anton V, Iqbal Mohammad Saeed
Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.
Department of Clinical Pharmacy, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia.
Polymers (Basel). 2022 Apr 27;14(9):1769. doi: 10.3390/polym14091769.
Modern dressings should provide for local delivery of antibiotics and protect the wound from bacterial infection, dehydration and environmental factors to achieve optimal healing. The local delivery of antibiotics can reduce adverse effects and resistance challenges. In this study, we fabricated film dressings composed of arabinoxylan (AX) from Plantago ovata seed husks and carboxymethylcellulose (CMC) by a solvent cast method for the delivery of the antibiotic amikacin (AMK). To determine the suitability of the prepared AX-CMC composite films as wound dressings and drug delivery materials, their physical, chemical, mechanical, morphological, thermal, pharmaceutical, antimicrobial, cytocompatible, and drug delivery properties were investigated. The results demonstrated that the dressings were suitable for delivering the drug at the wound site in a sustained manner and keeping the environment moist for rapid healing. The AMK-loaded AX-CMC films exhibited controlled release of AMK, excellent antibacterial activity, and cytocompatibility. Thus, the AX-CMC composite films appear to be promising bioactive dressing materials for the prevention of wound infections.
现代敷料应能实现抗生素的局部递送，并保护伤口免受细菌感染、脱水和环境因素影响，以实现最佳愈合效果。抗生素的局部递送可减少不良反应和耐药性问题。在本研究中，我们通过溶剂浇铸法制备了由来自卵叶车前籽壳的阿拉伯木聚糖（AX）和羧甲基纤维素（CMC）组成的薄膜敷料，用于递送抗生素阿米卡星（AMK）。为了确定所制备的AX-CMC复合膜作为伤口敷料和药物递送材料的适用性，我们对其物理、化学、机械、形态、热学、药学、抗菌、细胞相容性和药物递送性能进行了研究。结果表明，该敷料适合在伤口部位持续递送药物，并保持环境湿润以促进快速愈合。载有AMK的AX-CMC膜表现出AMK的控释、优异的抗菌活性和细胞相容性。因此，AX-CMC复合膜似乎是用于预防伤口感染的有前景的生物活性敷料材料。
