Alsaidan Omar A, Ahmad Naveed, Ejaz Hasan, Hussain Muhammad Ajaz, Zafar Ameeduzzafar, Alhassan Hassan H
Department of Pharmaceutics, College of Pharmacy, Jouf University Sakaka 72388 Aljouf Saudi Arabia
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University Sakaka 72388 Saudi Arabia.
RSC Adv. 2024 Aug 29;14(38):27520-27529. doi: 10.1039/d4ra02951h.
In an effort to prepare a modern polysaccharide-based dressing for sustained/prolonged delivery of the antibacterial agent to prevent and control skin wound infection, ciprofloxacin (CP)-loaded sodium alginate (SA)-chitosan (CS) nanoparticles (NPs) were incorporated into novel arabinoxylan (AX)-pectin (PC) blended polymeric films by solvent casting. The CP-NPs were prepared by a two-step ionic interaction method with < 300 nm size, about 25 mV zeta potential, 74% CP-loading efficiency, and approximately round shape. The CP-NPs were incorporated in optimized AX-PC polymeric film prepared by using 2% AX and 2% PC with a plasticizer (2% glycerol) and then these films were characterized for suitability as a film dressing. The transparency, improved mechanical strength, thermal stability, water transmission, and exudate uptake characteristics indicated that CP-NPs incorporated AX-PC polymeric films were suitable for dressing applications. The CP-NPs incorporated AX-PC films exhibited sustained CP release (90% release in 36 h) and better antibacterial susceptibility as compared to free CP-containing AX-PC films. Thus, CP-NPs incorporated AX-PC films are promising dressing materials to prevent and control wound infection with prolonged antibiotic release.
为了制备一种基于多糖的现代敷料，用于持续/长时间递送抗菌剂以预防和控制皮肤伤口感染，通过溶剂浇铸法将负载环丙沙星（CP）的海藻酸钠（SA）-壳聚糖（CS）纳米颗粒（NPs）掺入新型阿拉伯木聚糖（AX）-果胶（PC）共混聚合物薄膜中。CP-NPs通过两步离子相互作用法制备，粒径小于300 nm，zeta电位约为25 mV，CP负载效率为74%，形状近似圆形。将CP-NPs掺入通过使用2% AX和2% PC以及增塑剂（2%甘油）制备的优化AX-PC聚合物薄膜中，然后对这些薄膜作为敷料的适用性进行表征。透明度、改善的机械强度、热稳定性、水传输和渗出液吸收特性表明，掺入CP-NPs的AX-PC聚合物薄膜适用于敷料应用。与不含CP的AX-PC薄膜相比，掺入CP-NPs的AX-PC薄膜表现出CP的持续释放（36小时内释放90%）和更好的抗菌敏感性。因此，掺入CP-NPs的AX-PC薄膜是有望用于预防和控制伤口感染并实现抗生素长效释放的敷料材料。
