Washington University School of Medicine, St Louis, MO, USA.
Adv Exp Med Biol. 2022;1365:1-6. doi: 10.1007/978-981-16-8387-9_1.
Since their initial identification more than 10 years ago, innate lymphoid cells (ILCs) have emerged as denizens of an immune realm parallel to that of T cells. Here I highlight basic similarities shared by all and underscore features related to development, tissue residency and regulation that distinguish ILCs from T cells. I further discuss the potential of ILCs as promising targets for therapeutic intervention in human diseases.
自 10 多年前首次被鉴定以来，先天淋巴细胞（ILCs）已经成为与 T 细胞平行的免疫领域的居民。在这里，我强调了所有 ILCs 共有的基本特征，并强调了与发育、组织驻留和调节相关的特征，这些特征将 ILCs 与 T 细胞区分开来。我还进一步讨论了 ILCs 作为人类疾病治疗干预有希望的靶点的潜力。
