Epidemiology, IQVIA, Frankfurt, Germany.
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Pediatr Res. 2024 Jan;95(1):182-187. doi: 10.1038/s41390-022-02111-x. Epub 2022 May 14.
This study aimed to investigate the prevalence of and the factors associated with post-COVID-2019 condition in COVID-19 children and adolescents in Germany.
The present retrospective cohort study used data from the Disease Analyzer database (IQVIA), and included patients aged <18 years who were diagnosed with COVID-19 in one of 524 general and 81 pediatric practices in Germany between October 2020 and August 2021 (index date: first COVID-19 diagnosis). Post-COVID-19 condition was assessed between the index date and November 2021. Covariates included age, sex, type of practice, and chronic conditions documented in at least 1% of the population.
There were 6568 children and adolescents included in this study (mean [SD] age 10.1 [4.9] years; 49.2% girls). The prevalence of post-COVID-19 condition was 1.7% in the population. Patients aged 13-17 years were more likely to be diagnosed with post-COVID-19 condition compared with those being aged ≤5 years (RR = 3.14). Anxiety disorders (RR = 2.53), somatoform disorders (RR = 2.11), and allergic rhinitis (RR = 2.02) were also significantly associated with post-COVID-19 condition.
Post-COVID-19 condition was rare in COVID-19 children and adolescents in Germany. Data from other settings are warranted to confirm these findings.
The prevalence of post-COVID-19 condition was 1.7% in this population of children and adolescents. Older children and adolescents were more likely to be diagnosed with post-COVID-19 condition than their younger counterparts. Anxiety disorders, somatoform disorders, and allergic rhinitis were significantly associated with post-COVID-19 condition. More data from other settings and countries are warranted to corroborate or refute these findings.
本研究旨在调查德国 COVID-19 儿童和青少年中 COVID-19 后疾病的流行情况和相关因素。
本回顾性队列研究使用了 IQVIA 的 Disease Analyzer 数据库中的数据，纳入了 2020 年 10 月至 2021 年 8 月间德国 524 家普通诊所和 81 家儿科诊所中年龄<18 岁的诊断为 COVID-19 的患者（索引日期：首次 COVID-19 诊断）。COVID-19 后疾病的评估时间为索引日期至 2021 年 11 月。协变量包括年龄、性别、诊所类型和至少 1%人群中记录的慢性疾病。
本研究共纳入 6568 名儿童和青少年（平均[SD]年龄 10.1[4.9]岁；49.2%为女孩）。人群中 COVID-19 后疾病的患病率为 1.7%。与≤5 岁的患者相比，13-17 岁的患者更有可能被诊断为 COVID-19 后疾病（RR=3.14）。焦虑障碍（RR=2.53）、躯体形式障碍（RR=2.11）和过敏性鼻炎（RR=2.02）也与 COVID-19 后疾病显著相关。
德国 COVID-19 儿童和青少年 COVID-19 后疾病罕见。需要其他地区的数据来证实这些发现。
在该人群的儿童和青少年中，COVID-19 后疾病的患病率为 1.7%。年龄较大的儿童和青少年比年龄较小的儿童和青少年更有可能被诊断为 COVID-19 后疾病。焦虑障碍、躯体形式障碍和过敏性鼻炎与 COVID-19 后疾病显著相关。需要来自其他地区和国家的更多数据来证实或反驳这些发现。
