Kostev Karel, Smith Lee, Koyanagi Ai, Jacob Louis
Epidemiology, IQVIA, Frankfurt, Germany.
Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, United Kingdom.
Open Forum Infect Dis. 2022 Jul 4;9(7):ofac333. doi: 10.1093/ofid/ofac333. eCollection 2022 Jul.
Little is known about the epidemiology of post-coronavirus disease 2019 (COVID-19) condition (PCC) in primary care practices. Therefore, this study aimed to investigate the prevalence of and the factors associated with PCC in the 12 months after the diagnosis of COVID-19 in patients followed in general practices in Germany.
This retrospective cohort study included adults aged ≥18 years who were diagnosed for the first time with COVID-19 (index date) in 1 of 855 general practices in Germany between October 2020 and August 2021 (Disease Analyzer database; IQVIA). The outcome was the occurrence of PCC 91 to 365 days after the index date. Covariates included age, sex, and comorbidities documented in the 12 months before the index date. The association between covariates and PCC was assessed using a multivariable logistic regression model.
We included 51 630 patients in this study (mean age, 47.1 [standard deviation, 19.8] years; 54.3% women). The prevalence of PCC was 8.3%. Age >30 years (odds ratios [ORs] ranging from 1.40 for 31-45 years to 2.10 for 46-60 years) and female sex (OR = 1.23) were positively and significantly associated with PCC compared with age 18-30 years and male sex, respectively. There was also a significant relationship of PCC with asthma (OR = 1.38), reaction to severe stress, and adjustment disorders (OR = 1.24), and somatoform disorders (OR = 1.23).
Post-COVID-19 condition was found in the 12 months after the diagnosis of COVID-19 in approximately 8% of adults from general practices in Germany. More data from other settings are warranted to confirm these findings.
对于基层医疗实践中2019冠状病毒病（COVID-19）后状况（PCC）的流行病学情况，人们了解甚少。因此，本研究旨在调查德国普通诊所中确诊COVID-19后12个月内PCC的患病率及其相关因素。
这项回顾性队列研究纳入了2020年10月至2021年8月期间在德国855家普通诊所中首次被诊断为COVID-19（索引日期）的≥18岁成年人（疾病分析器数据库；艾昆纬公司）。结局指标是索引日期后91至365天内PCC的发生情况。协变量包括索引日期前12个月内记录的年龄、性别和合并症。使用多变量逻辑回归模型评估协变量与PCC之间的关联。
本研究纳入了51630名患者（平均年龄47.1[标准差19.8]岁；54.3%为女性）。PCC的患病率为8.3%。与18至30岁年龄组和男性相比，年龄>30岁（31至45岁的比值比[OR]为1.40，46至60岁的OR为2.10）和女性（OR = 1.23）与PCC呈显著正相关。PCC还与哮喘（OR = 1.38）、对严重应激的反应和适应障碍（OR = 1.24）以及躯体形式障碍（OR = 1.23）存在显著关系。
在德国普通诊所中，约8%的成年人在确诊COVID-19后12个月内出现了COVID-19后状况。需要来自其他环境的更多数据来证实这些发现。
