工程细菌膜纳米囊泡用于改善传染病和癌症的治疗。
Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer.
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA.
出版信息
Adv Drug Deliv Rev. 2022 Jul;186:114340. doi: 10.1016/j.addr.2022.114340. Epub 2022 May 13.
Research on bacterial membrane vesicles (BMVs) is an emerging topic, and the goal is to address whether BMVs can bring translational tools to improve current therapies. In this review, we provided the updated studies on BMVs including their production, their types, and therapeutic regimens for treating infectious diseases and cancers. We described several platforms of BMVs, such as outer membrane vesicles (OMVs), inner membrane vesicles (IMVs) and double membrane vesicles (DMVs), and those structures were produced from Gram-negative or Gram-positive bacteria. We also discussed how to engineer and formulate new and novel BMVs using chemical, physical, and genetic methods. For therapies, we analyzed current methods for loading drugs in BMVs and discussed their limitations. Finally, we reviewed several therapeutic platforms of BMVs that have been exploited in improving the treatments of infectious diseases and cancers. Although BMVs offer the promising biomedical applications, it is needed to develop rigorous approaches and methods to generate reproducible and scalable drug delivery systems for translation.
细菌膜泡（BMVs）的研究是一个新兴的课题，其目标是探讨 BMV 是否可以带来转化工具来改进当前的治疗方法。在这篇综述中，我们提供了关于 BMV 的最新研究，包括它们的产生、类型以及治疗传染病和癌症的治疗方案。我们描述了几种 BMV 平台，如外膜泡（OMVs）、内膜泡（IMVs）和双膜泡（DMVs），这些结构是由革兰氏阴性或革兰氏阳性细菌产生的。我们还讨论了如何使用化学、物理和遗传方法来设计和构建新型 BMV。在治疗方面，我们分析了目前在 BMV 中加载药物的方法，并讨论了它们的局限性。最后，我们回顾了几种已经被开发用于改善传染病和癌症治疗的 BMV 治疗平台。尽管 BMV 提供了有前途的生物医学应用，但仍需要开发严格的方法和途径，以生成可重复和可扩展的药物输送系统，实现转化。
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