[具体药物名称]在正常及链脲佐菌素诱导的糖尿病大鼠中的降糖和降脂作用
Antihyperglycemic and Antidyslipidemic Effect of in Normal and Streptozotocin-induced Diabetic Rats.
作者信息
Azzane Amine, Amssayef Ayoub, Eddouks Mohamed
机构信息
Team of Ethnopharmacology & Pharmacognosy, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, BP 509, Boutalamine, 52000. Errachidia. Morocco.
出版信息
Cardiovasc Hematol Disord Drug Targets. 2022;22(1):58-66. doi: 10.2174/1871529X22666220513124452.
AIMS
The present work aimed to assess the antihyperglycemic and antihyperlipidemic effects of Moricandia suffruticosa.
BACKGROUND
Moricandia suffruticosa (M. suffruticosa) is used in traditional medicine.
OBJECTIVE
The present study investigated the antihyperglycemic and antidyslipidemic effects of M. suffruticosa and its effect on glycogen content in normoglycemic and hyperglycemic rats.
METHODS
The effect of the aqueous extract of M. suffruticosa (AEMS) at two doses of 100 and 140 mg/kg on blood glucose levels, lipid, lipoprotein profile, and glycogen content was examined in normal and streptozotocin (STZ)-induced diabetic rats. Moreover, preliminary phytochemical screening and quantification of phenolic, flavonoid, and tannin contents were carried out.
RESULTS
The results demonstrated that AEMS exhibits antihyperglycemic activity in diabetic rats during both acute and subchronic assays. Furthermore, AEMS revealed an antidyslipidemic effect concerning the level of triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), and non-high-density lipoproteins (Non-HDL). In contrast, AEMS has not affected the value of glycemia, lipids, and lipoproteins in normal rats. In addition, AEMS is rich in several phytochemical compounds. Furthermore, AEMS revealed an important in vitro antioxidant activity.
CONCLUSION
In conclusion, the study demonstrates that M. suffruticosa exhibits an important antihyperglycemic effect in diabetic rats.
目的
本研究旨在评估钻叶紫菀的降血糖和降血脂作用。
背景
钻叶紫菀在传统医学中有所应用。
目的
本研究调查了钻叶紫菀的降血糖和抗血脂异常作用及其对正常血糖和高血糖大鼠糖原含量的影响。
方法
在正常大鼠和链脲佐菌素（STZ）诱导的糖尿病大鼠中，检测了100和140mg/kg两种剂量的钻叶紫菀水提取物（AEMS）对血糖水平、脂质、脂蛋白谱和糖原含量的影响。此外，还进行了初步的植物化学筛选以及酚类、黄酮类和单宁含量的定量分析。
结果
结果表明，在急性和亚慢性试验中，AEMS在糖尿病大鼠中均表现出降血糖活性。此外，AEMS在甘油三酯、总胆固醇、极低密度脂蛋白（VLDL）和非高密度脂蛋白（Non-HDL）水平方面显示出抗血脂异常作用。相比之下，AEMS对正常大鼠的血糖、脂质和脂蛋白值没有影响。此外，AEMS富含多种植物化学化合物。此外，AEMS还显示出重要的体外抗氧化活性。
结论
总之，该研究表明钻叶紫菀在糖尿病大鼠中表现出重要的降血糖作用。
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