Ghodsi Mohammad, Hojati Vida, Attaranzadeh Armin, Saifi Bita
Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.
Imam Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran.
Int J Reprod Biomed. 2022 Apr 21;20(3):213-220. doi: 10.18502/ijrm.v20i3.10713. eCollection 2021 Mar.
Endometriosis is associated with abnormal immunologic responses and combined inflammatory and anti-inflammatory conditions.
This study aims to investigate follicular fluid (FF) concentration of interleukin (IL)-3, IL-5, and IL-6 in women with and without endometriosis.
In this cross-sectionalstudy 68 women who were referred to the in vitro fertilization center of Imam Reza hospital in Mashhad during 2018 were selected randomly. Leaves of cytokines in the FF samples were evaluated in the endometriosis and the control group (n = 34/each). The diagnostic accuracy of cytokines and clinical characteristics were evaluated.
IL-3 and IL-6 were significantly changed in the FF of the women with endometriosis compared with the control group (p = 0.04, and p 0.01, respectively), and the mean concentration of IL-5 in the endometriosis group was lower than in the control group (p = 0.5), but this was not significant. There were significant differences in the menstrual cycle, dyspareunia, and dysmenorrhea between the groups (p 0.01, p = 0.04, and p = 0.02, respectively). The diagnostic accuracy of IL-3 and IL-6 in the FF was low, with the area under the curve of 0.614 and 0.645, respectively.
Although none of the cytokines had a predictive value for endometriosis, the decreased levels of IL-3 and increased levels of IL-6 in the FF samples of women with endometriosis, and risk factors, including irregular menstrual cycle, dyspareunia, and dysmenorrhea, could be associated with the pathogenesis of this painful disease.
子宫内膜异位症与异常免疫反应以及炎症和抗炎状态的联合存在有关。
本研究旨在调查有和没有子宫内膜异位症的女性卵泡液（FF）中白细胞介素（IL）-3、IL-5和IL-6的浓度。
在这项横断面研究中，随机选择了2018年期间转诊至马什哈德伊玛目礼萨医院体外受精中心的68名女性。在子宫内膜异位症组和对照组（每组n = 34）中评估FF样本中细胞因子的水平。评估细胞因子的诊断准确性和临床特征。
与对照组相比，子宫内膜异位症女性的FF中IL-3和IL-6有显著变化（分别为p = 0.04和p < 0.01），子宫内膜异位症组中IL-5的平均浓度低于对照组（p = 0.5），但差异不显著。两组之间在月经周期、性交困难和痛经方面存在显著差异（分别为p < 0.01、p = 0.04和p = 0.02）。FF中IL-3和IL-6的诊断准确性较低，曲线下面积分别为0.614和0.645。
尽管没有一种细胞因子对子宫内膜异位症有预测价值，但子宫内膜异位症女性FF样本中IL-3水平降低和IL-6水平升高，以及包括月经周期不规律、性交困难和痛经在内的危险因素，可能与这种疼痛性疾病的发病机制有关。
