Ava Sedat, Hazar Leyla, Karahan Mine, Erdem Seyfettin, Dursun Mehmet Emin, Pekkolay Zafer, Keklikçi Uğur
Department of Ophthalmology, Dicle University School of Medicine, Diyarbakır, Turkey.
Department of Endocrinology and Metabolism, Dicle University School of Medicine, Diyarbakır, Turkey.
Neuroophthalmology. 2022 Jan 25;46(3):154-158. doi: 10.1080/01658107.2021.2021247. eCollection 2022.
The aim of this study was to determine whether the dopamine agonist (DA) drug cabergoline used in the treatment of prolactinoma causes autonomic dysfunction by measuring static and dynamic pupillary responses. The study included 25 eyes from 25 patients who were receiving DA for the treatment of prolactinoma and 25 eyes from 25 healthy individuals. Static and dynamic pupillary responses were measured by automatic quantitative pupillometry. The scotopic pupillary diameter was found to be significantly higher in patients receiving DA medication compared with the control group, while pupil contraction time and pupillary dilatation latency were significantly lower. DA drug use changes static and dynamic pupillary responses, probably by increasing sympathetic tone. Pupillometry can be used as a non-invasive method to provide information about changes in the autonomic nervous system in patients receiving such drug therapy.
本研究的目的是通过测量静态和动态瞳孔反应，确定用于治疗泌乳素瘤的多巴胺激动剂（DA）药物卡麦角林是否会导致自主神经功能障碍。该研究纳入了25例接受DA治疗泌乳素瘤的患者的25只眼睛，以及25名健康个体的25只眼睛。通过自动定量瞳孔测量法测量静态和动态瞳孔反应。发现接受DA药物治疗的患者与对照组相比，暗视瞳孔直径显著更高，而瞳孔收缩时间和瞳孔扩张潜伏期显著更低。使用DA药物可能通过增加交感神经张力来改变静态和动态瞳孔反应。瞳孔测量法可作为一种非侵入性方法，用于提供接受此类药物治疗患者自主神经系统变化的信息。
