Effect of vitrectomy with silicone oil tamponade and internal limiting membrane peeling on eyes with proliferative diabetic retinopathy.

We investigated the combined effect of silicone tamponade and the internal limiting membrane (ILM) peeling and investigated whether timing of peeling of the ILM affects the outcomes of vitrectomy with silicone oil tamponade in eyes with proliferative diabetic retinopathy (PDR). Here, we examined 63 eyes (58 patients) with PDR, which underwent vitrectomy with silicone oil tamponade and stepwise removal of silicone oil. ILM peeling was performed just before oil injection (group 1; 33 eyes, 30 patients) or after oil removal (group 2; 30 eyes, 28 patients). Visual acuity and retinal and choroidal thicknesses were compared between the groups. Thinning of the inner retina, including the ganglion cell-inner plexiform layer and macular retinal nerve fiber layer, was evident at 1 year after surgery in both groups. Thinning of the total retina (P = 0.019) and inner retina (P = 0.008) was significantly correlated with final visual acuity. There was no considerable between-group difference observed in final visual acuity, intraocular pressure, or retinal or choroidal thickness at 1 year after surgery. The incidence of epiretinal membrane was higher during silicone endo-tamponade in group 2 (P = 0.033). Visual recovery and macular configuration in eyes with PDR are not affected by whether the ILM is peeled before or after silicone oil tamponade.