Eid Mohamed, Mounir Amr, El Etriby Shehab, Al Taher Ali, Ezzat Mohamed A W
Department of Internal Medicine, Sohag University Hospital, Sohag University, Sohag, Egypt.
Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.
Diabetes Metab Syndr Obes. 2022 May 11;15:1485-1494. doi: 10.2147/DMSO.S363406. eCollection 2022.
Diabetic retinopathy (DR) is one of the most prevalent consequences of diabetes mellitus (DM). Much emphasis has been focused on the link between DR and cardiovascular disorders in patients with type 2 diabetes (T2DM). However, there is little information about the relation between the degree of DR and coronary atherosclerosis severity in Egyptian patients.
To assess the correlation between the degree of DR and the coronary atherosclerosis severity in T2DM.
This work included 140 diabetic patients with T2DM who underwent diagnostic coronary angiography because of suspected coronary artery disease (CAD). All participants were evaluated by history, fundus assessment, laboratory tests (lipid profile and glycated hemoglobin [HbA1c]), and selective coronary angiography. The severity of coronary artery lesion was detected by Gensini score and vessel score.
Patients with DR had a significantly higher Gensini score (67.86± 44.56 versus 5.93± 9.02, P < 0.001) and a vessel score (2.29± 0.86 versus 0.50± 0.66, P < 0.001). There was a significant relation between the degree of DR, Gensini score (P < 0.001), and vessel score (P < 0.001), as both scores increased according to the severity of DR. The presence and degree of retinopathy were the only independent factors linked to the severity score in multivariate linear regression analyses (P < 0.001).
The presence and degree of DR are independent predictors of severe coronary atherosclerosis. Therefore, when evaluating whether a patient with T2DM is at high risk for CAD, the DR degree should be taken into consideration.
糖尿病视网膜病变（DR）是糖尿病（DM）最常见的并发症之一。2型糖尿病（T2DM）患者中，DR与心血管疾病之间的联系受到了广泛关注。然而，关于埃及患者DR程度与冠状动脉粥样硬化严重程度之间的关系，相关信息较少。
评估T2DM患者DR程度与冠状动脉粥样硬化严重程度之间的相关性。
本研究纳入了140例因疑似冠状动脉疾病（CAD）而接受诊断性冠状动脉造影的T2DM患者。所有参与者均通过病史、眼底评估、实验室检查（血脂谱和糖化血红蛋白[HbA1c]）以及选择性冠状动脉造影进行评估。冠状动脉病变的严重程度通过Gensini评分和血管评分来检测。
DR患者的Gensini评分（67.86±44.56 vs 5.93±9.02，P<0.001）和血管评分（2.29±0.86 vs 0.50±0.66，P<0.001）显著更高。DR程度与Gensini评分（P<0.001）和血管评分（P<0.001）之间存在显著关系，随着DR严重程度的增加，两个评分均升高。在多变量线性回归分析中，视网膜病变的存在和程度是与严重程度评分相关的唯一独立因素（P<0.001）。
DR的存在和程度是严重冠状动脉粥样硬化的独立预测因素。因此，在评估T2DM患者是否具有CAD高风险时，应考虑DR程度。
