Watanabe Yoshihiro, Yoshida Yurika, Tokiwa Toshiyuki, Higo Mayuka, Ban Sayaka, Ikeda Akari, Noguchi Yoshihiko, Hirose Tomoyasu, Sunazuka Toshiaki, Nonaka Kenichi, Yaguchi Takashi, Iwatsuki Masato
Ōmura Satoshi Memorial Institute, Kitasato University.
Graduate School of Infection Control Sciences, Kitasato University.
J Gen Appl Microbiol. 2022 Nov 22;68(4):200-206. doi: 10.2323/jgam.2022.03.002. Epub 2022 May 20.
A new antifungal polyketide, named hakuhybotric acid (1), was isolated from a cultured broth of a mycoparasitic fungus Hypomyces pseudocorticiicola FKI-9008, together with two known analogs, F2928-1 (2) and Cladobotric acid E (3). Their structures were elucidated by MS and NMR analyses. Hakuhybotric acid was a new analog of Cladobotric acid where two epoxy groups in F2928-1 were replaced with olefins. All compounds showed antifungal activity against four different species of Aspergillus spp., the causative agents of aspergillosis. It was suggested that mycoparasitic fungi are a useful source to search antifungal drug lead compounds.
从寄生真菌拟皮层生腐菌Hypomyces pseudocorticiicola FKI-9008的培养液中分离出一种新的抗真菌聚酮化合物，命名为白黄柄曲酸（1），同时还分离出两个已知类似物，F2928-1（2）和枝状柄曲酸E（3）。通过质谱和核磁共振分析确定了它们的结构。白黄柄曲酸是枝状柄曲酸的一种新类似物，其中F2928-1中的两个环氧基被烯烃取代。所有化合物对四种不同的曲霉属物种均表现出抗真菌活性，这些曲霉属物种是曲霉病的病原体。研究表明，寄生真菌是寻找抗真菌药物先导化合物的有用来源。
