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基于宏基因组测序的中国广西地区与其他灵长类动物的比较肠道微生物组。

Comparative Gut Microbiome in and Other Primates in Guangxi, China, Based on Metagenome Sequencing.

机构信息

Terrestrial Wildlife Rescue and Epidemic Diseases Surveillance Center of Guangxi, Nanning, China.

Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application, Guangxi Medical University, Nanning, China.

出版信息

Front Cell Infect Microbiol. 2022 May 4;12:872841. doi: 10.3389/fcimb.2022.872841. eCollection 2022.

DOI:10.3389/fcimb.2022.872841
PMID:35601103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9114771/
Abstract

The (white-headed langur) is a highly endangered, karst-endemic primate species, inhabiting the karst limestone forest in Guangxi, Southwest China. How white-headed langurs adapted to karst limestone and special dietary remains unclear. It is the first time to study the correlation between the gut microbiome of primates and special dietary, and environment in Guangxi. In the study, 150 fecal samples are collected from nine primates in Guangxi, China. Metagenomic sequencing is used to analyze and compare the gut microbiome composition and diversity between white-headed langurs and other primates. Our results indicate that white-headed langurs has a higher diversity of microbiome than other primates, and the key microbiome are phylum Firmicutes, class Clostridia, family Lachnospiraceae, and genera and , which are related to the digestion and degradation of cellulose. Ten genera are significantly more abundant in white-headed langurs and François' langur than in other primates, most of which are high-temperature microbiome. Functional analysis reveals that energy synthesis-related pathways and sugar metabolism-related pathways are less abundant in white-headed langurs and François' langur than in other primates. This phenomenon could be an adaptation mechanism of leaf-eating primates to low-energy diet. The gut microbiome of white-headed langurs is related to diet and karst limestone environment. This study could serve as a reference to design conservation breeding, manage conservation units, and determine conservation priorities.

摘要

白头叶猴（white-headed langur）是一种高度濒危的喀斯特特化灵长类物种，栖息在中国西南部广西的喀斯特石灰林地。白头叶猴如何适应喀斯特石灰岩和特殊饮食尚不清楚。这是首次研究广西灵长类动物的肠道微生物组与特殊饮食和环境之间的相关性。在这项研究中，从中国广西的 9 只灵长类动物中收集了 150 个粪便样本。使用宏基因组测序来分析和比较白头叶猴和其他灵长类动物的肠道微生物组组成和多样性。我们的研究结果表明，白头叶猴的微生物组多样性高于其他灵长类动物，关键微生物组是厚壁菌门、梭菌纲、lachnospiraceae 科和属 和 ，它们与纤维素的消化和降解有关。有 10 个属在白头叶猴和黑叶猴中比在其他灵长类动物中更为丰富，其中大多数属于高温微生物组。功能分析表明，能量合成相关途径和糖代谢相关途径在白头叶猴和黑叶猴中的丰度低于其他灵长类动物。这种现象可能是食叶灵长类动物适应低能量饮食的一种适应机制。白头叶猴的肠道微生物组与饮食和喀斯特石灰岩环境有关。本研究可为设计保护繁殖、管理保护区和确定保护优先级提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/9af221ac5b50/fcimb-12-872841-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/23ec9a59f4b3/fcimb-12-872841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/2b452286e979/fcimb-12-872841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/dd36ff0f6a6b/fcimb-12-872841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/e1235a60c4d2/fcimb-12-872841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/15e51bd55a80/fcimb-12-872841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/005a851723b3/fcimb-12-872841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/c3883a037e3d/fcimb-12-872841-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/9af221ac5b50/fcimb-12-872841-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/23ec9a59f4b3/fcimb-12-872841-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/2b452286e979/fcimb-12-872841-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/dd36ff0f6a6b/fcimb-12-872841-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/e1235a60c4d2/fcimb-12-872841-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/15e51bd55a80/fcimb-12-872841-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/005a851723b3/fcimb-12-872841-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/c3883a037e3d/fcimb-12-872841-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d58/9114771/9af221ac5b50/fcimb-12-872841-g008.jpg

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