中医药在缓解老年失眠中的作用及临床观察：系统评价和荟萃分析。
The Role and Clinical Observation of Traditional Chinese Medicine in Relieving Senile Insomnia: A Systematic Review and Meta-Analysis.
机构信息
Department of Traditional Medicine, Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China.
Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine 200120, Shanghai 200120, China.
出版信息
Biomed Res Int. 2022 May 13;2022:9484095. doi: 10.1155/2022/9484095. eCollection 2022.
OBJECTIVE
To assess the role and clinical observation of traditional Chinese medicine (TCM) in relieving senile insomnia and conduct a systematic evaluation and meta-analysis.
METHODS
We searched Chinese literatures from some database, including the China Knowledge Network database, Chongqing CQVIP Chinese database, Wanfang database, and Chinese Biomedical Literature database. In addition, English literature retrieval database PubMed and the Cochrane Library were included in this meta-analysis. The randomized controlled trial (RCT) of cognitive behavioral therapy was found in the treatment of chronic insomnia. All articles were current up to December 1, 2021, and references in the literature were hand searched.
RESULTS
About 16 studies were included, involving 1260 elderly patients with insomnia. Meta-analysis results showed that compared with the control group, the sleep latency of the experimental group MD = -8.02, 95% CI (10.95, 5.01), the number of awakenings of the experimental group MD = -0.41, 95% CI (0.68, 0.14), the total sleep time of the experimental group MD = 39.41, 95% CI (27.05, 51.71), the sleep efficiency of the experimental group MD = 7.82, 95% CI (1.87, 13.75) the Pittsburgh sleep quality index of the experimental group MD = 2.41, 95% CI (3.12, 1.46), the effective rate of the experimental group: OR = 3.12, 95% CI (1.76, 5.48), and the insomnia severity index of the experimental group MD = 1.05, 95% CI (2.04, 0.52).
CONCLUSION
Our current study has indicated that TCM may play a central role in relieving senile insomnia and may be effective when treating insomnia. However, due to the low quality of trial methodology and publication bias, it cannot be fully confirmed. Further high-quality trials are needed to be investigated in the future.
目的
评估中医药在缓解老年失眠症中的作用并进行系统评价和荟萃分析。
方法
我们检索了中国的一些数据库，包括中国知网数据库、重庆维普中文数据库、万方数据库和中国生物医学文献数据库。此外，还包括英文文献检索数据库 PubMed 和 Cochrane Library 进行荟萃分析。发现认知行为疗法治疗慢性失眠症的随机对照试验（RCT）。所有文章均为截至 2021 年 12 月 1 日的最新文章，并检索了文献中的参考文献。
结果
纳入了约 16 项研究，涉及 1260 例老年失眠症患者。荟萃分析结果显示，与对照组相比，实验组的睡眠潜伏期 MD=-8.02，95%CI（10.95，5.01），实验组的觉醒次数 MD=-0.41，95%CI（0.68，0.14），实验组的总睡眠时间 MD=39.41，95%CI（27.05，51.71），实验组的睡眠效率 MD=7.82，95%CI（1.87，13.75），实验组匹兹堡睡眠质量指数 MD=2.41，95%CI（3.12，1.46），实验组的有效率：OR=3.12，95%CI（1.76，5.48），实验组的失眠严重指数 MD=1.05，95%CI（2.04，0.52）。
结论
本研究表明，中医药可能在缓解老年失眠症中发挥重要作用，对失眠的治疗可能有效。但是，由于试验方法学质量低和发表偏倚，尚不能完全证实。未来需要进一步开展高质量的试验。
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