Luo Xuemei, Wu Feifeng, Wang Cheng, Wen Chuan
Department of Pediatrics, The Second Xiangya Hospital, Central South University, Changsha, China.
Front Pediatr. 2022 May 6;10:899844. doi: 10.3389/fped.2022.899844. eCollection 2022.
Using multivariate statistics and social network analysis techniques, we present a realistic and intuitive visualization of the research hotspots and development trends of vitamin D in children.
The Medical Subject Headings (MeSH) term "vitamin D" was used to search all the publications (the study subjects were 0-18 years old) included in PubMed by time period. The subject terms for each development stage were extracted, the high-frequency subject terms were extracted using the Bibliographic Items Co-occurrence Matrix Builder (BICOMB), and a core subject term co-occurrence matrix was established. The Netdraw function of Ucinet 6.0 software was used to complete the social network drawing of the core subject term co-occurrence matrix to form a co-word network diagram composed of core subject terms.
Prior to 1979, there were 890 papers with 1,899 core subject terms; from 2010 to 2020, there were 3,773 papers with 12,682 core subject terms. Before 1979, the research direction of vitamin D in children focused on vitamin D in the classical regulation of calcium and phosphorus metabolism. From 1980 to 1989, studies focused on vitamin D metabolites and therapeutic drugs such as "calcitriol" and "calcifediol." From 1990 to 1999, studies focused on "calcitriol" and its association with "psoriasis," "chronic renal failure," and "dermatological drugs." From 2000 to 2009, studies focused on "vitamin D" and "vitamin D deficiency." From 2010 to 2020, studies focused on "vitamin D" and its association with "vitamins," "bone mineral density protectants," "asthma," "obesity," "pregnancy complications" and "fetal blood."
Since 2010, the research direction of vitamin D in children has been growing rapidly, and the overall development trend is good. Studies extend from the study of the skeletal effect of vitamin D to the study of its extraskeletal effect and the investigation of mechanisms of its association with related diseases.
运用多元统计和社会网络分析技术，呈现儿童维生素D研究热点及发展趋势的真实且直观的可视化结果。
使用医学主题词（MeSH）“维生素D”，按时间段检索PubMed中纳入的所有出版物（研究对象为0至18岁）。提取每个发展阶段的主题词，使用文献共现矩阵构建器（BICOMB）提取高频主题词，并建立核心主题词共现矩阵。使用Ucinet 6.0软件的Netdraw功能完成核心主题词共现矩阵的社会网络绘图，形成由核心主题词组成的共词网络图。
1979年以前，有890篇论文，1899个核心主题词；2010年至2020年，有3773篇论文，12682个核心主题词。1979年以前，儿童维生素D的研究方向集中在维生素D在钙磷代谢经典调节方面。1980年至1989年，研究集中在维生素D代谢产物及治疗药物如“骨化三醇”和“阿法骨化醇”。1990年至1999年，研究集中在“骨化三醇”及其与“银屑病”“慢性肾衰竭”和“皮肤科药物”的关联。2000年至2009年，研究集中在“维生素D”和“维生素D缺乏”。2010年至2020年，研究集中在“维生素D”及其与“维生素”“骨密度保护剂”“哮喘”“肥胖”“妊娠并发症”和“胎儿血液”的关联。
自2010年以来，儿童维生素D的研究方向发展迅速，总体发展趋势良好。研究从维生素D的骨骼效应研究扩展到其骨骼外效应研究以及与相关疾病关联机制的探究。
