SCDU of Pediatrics, Azienda Ospedaliero-Universitaria Maggiore della Carità, University of Piemonte Orientale, 28100 Novara, Italy.
Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, Italy.
Int J Mol Sci. 2020 May 16;21(10):3536. doi: 10.3390/ijms21103536.
Vitamin D (25OHD) pleiotropic effects are widely recognized and studied. Recently, vitamin D cardiovascular effects are gaining interest, especially in children, although the studies present conflicting data. Some randomized controlled trials (RCTs) have demonstrated that cardiovascular risk markers, such as lipid parameters, inflammation markers, blood pressure, and arterial stiffness, are unaffected by vitamin D supplementation. By contrast, other studies show that low vitamin D levels are associated with higher risk of cardiovascular disease (CVD) and mortality, and support that increased risk of these diseases occurs primarily in people with vitamin D deficiency. An update on these points in pediatric patients is certainly of interest to focus on possible benefits of its supplementation.
维生素 D（25OHD）的多效作用已被广泛认识和研究。最近，维生素 D 的心血管作用引起了关注，特别是在儿童中，尽管这些研究的数据存在矛盾。一些随机对照试验（RCT）表明，心血管风险标志物，如血脂参数、炎症标志物、血压和动脉僵硬度，不受维生素 D 补充的影响。相比之下，其他研究表明，维生素 D 水平低与心血管疾病（CVD）和死亡率的风险增加相关，并支持这些疾病的风险增加主要发生在维生素 D 缺乏的人群中。儿科患者在这些方面的最新进展肯定值得关注，以了解其补充的可能益处。
