维生素 E 和维生素 C 对男性不育的影响：荟萃分析。
Effects of vitamin E and vitamin C on male infertility: a meta-analysis.
机构信息
Department of Nephrology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Department of Traditional Chinese Medicine, The First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Guangzhou, 510630, Guangdong, China.
出版信息
Int Urol Nephrol. 2022 Aug;54(8):1793-1805. doi: 10.1007/s11255-022-03237-x. Epub 2022 May 23.
PURPOSE
The efficacy of the antioxidants vitamin E (VitE) and vitamin C (VitC) on male infertility is uncertain. Therefore, this research systematically assessed the influences of VitE and VitC on male infertility.
METHODS
We did a meta-analysis of randomized controlled trials (RCTs) to analyze semen parameters, pregnancy rate, and adverse effects (AEs) between VitE and VitC groups and control groups by searching Cochrane Library, Excerpta Medica Database (Embase), PubMed, China Biology Medicine disc (CBMdisc), and Web of Science up to June 2020.
RESULTS
We screened 11 studies (832 patients) that met the inclusion criteria. The evidence quality ranged from moderate to low. The pregnancy rate was obviously better in the VitE group than in the control group (relative risk (RR) 1.86, 95% confidence interval (CI) 1.02-3.41). Compared with the control group, VitE and VitC significantly improved progressive motility (standardized mean difference (SMD) 0.38, 95% CI 0.22-0.55), sperm concentration (SMD 0.21, 95% CI 0.09-0.34), sperm morphology (SMD 0.32, 95% CI 0.09-0.55), and total sperm number (SMD 0.28, 95% CI 0.12-0.43) without AEs.
CONCLUSION
This study suggests that VitC and VitE can improve the spousal pregnancy rate and semen parameters in infertile men without AEs.
目的
抗氧化剂维生素 E（VitE）和维生素 C（VitC）对男性不育症的疗效尚不确定。因此，本研究系统评估了 VitE 和 VitC 对男性不育症的影响。
方法
我们对 Cochrane 图书馆、Excerpta Medica Database（Embase）、PubMed、中国生物医学文献数据库（CBMdisc）和 Web of Science 进行了系统检索，以检索截至 2020 年 6 月的随机对照试验（RCTs），分析 VitE 和 VitC 组与对照组之间的精液参数、妊娠率和不良反应（AE）。
结果
我们筛选出符合纳入标准的 11 项研究（832 例患者）。证据质量从中等到低。VitE 组的妊娠率明显优于对照组（相对风险（RR）1.86，95%置信区间（CI）1.02-3.41）。与对照组相比，VitE 和 VitC 可显著提高前向运动精子百分率（标准化均数差（SMD）0.38，95%CI 0.22-0.55）、精子浓度（SMD 0.21，95%CI 0.09-0.34）、精子形态（SMD 0.32，95%CI 0.09-0.55）和总精子数（SMD 0.28，95%CI 0.12-0.43），且无不良反应。
结论
本研究表明，VitC 和 VitE 可提高不育男性的配偶妊娠率和精液参数，且无不良反应。
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