Faculty of Pharmacy, Karpagam Academy of Higher Education, Salem-Kochi Highway, Eachanari, Coimbatore, India.
Centre for Nano Sciences and Molecular Medicine, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi, 682041, Kerala, India; Microbial Genetics, Interfaculty Institute of Microbiology and Infection Medicine Tubingen (IMIT) University of Tubingen, Tubingen, Germany.
Microb Pathog. 2022 Jul;168:105594. doi: 10.1016/j.micpath.2022.105594. Epub 2022 May 21.
Helicobacter pylori is a Gram-negative, spiral-shaped bacillus that colonizes 50% of the world population and is considered a class 1 carcinogen by the World Health Organization. This pathogen is the most common cause of infection-related cancers. Apart from cancer, it also causes several gastric and extra gastric diseases. Eradication of H. pylori using antibiotics is a global challenge because of its drug resistance. Alternative treatment options are gaining more attention to tackle drug-resistant H. pylori infections. Several medicinal plants and their isolated compounds have been reported for their antimicrobial activity against H. pylori. The mechanism of action of many of these plant extracts and plant-derived compounds is different from that of conventional antibiotics. Therefore they are shown to be effective against drug-resistant strains of H. pylori. They act by inhibiting bacterial enzymes, adhesions with gastric mucosa, suppression of nuclear factor-κB and by inhibition of oxidative stress. Extracts from Pistacia lentiscus, Brassica oleracea, Glycyrrhiza glabra, Camellia sinensis, Cinnamomum cassia, Allium sativum and Nigella sativa plants and isolated phyto-compounds such as curcumin, resveratrol, quercetin, allicin and ellagic acid demonstrated antimicrobial activity against H. pylori under in vivo conditions. The plant extracts of Zingiber officinale, Glycyrrhiza glabra; and phytochemical allicin and berberine when combined with standard treatment, result in a dramatic increase in H. pylori eradication. In this review, we highlighted the therapeutic efficacy of different plant extracts and isolated phyto compounds against H. pylori infection and described their role in tackling H. pylori resistance to antibiotics.
幽门螺杆菌是一种革兰氏阴性、螺旋形杆菌，定植于全球 50%的人口中，被世界卫生组织列为 1 类致癌物。这种病原体是感染相关癌症最常见的病因。除了癌症，它还会引起多种胃部和胃部以外的疾病。由于其耐药性，用抗生素根除幽门螺杆菌是一个全球性的挑战。替代治疗方案越来越受到关注，以解决耐药性幽门螺杆菌感染问题。已有报道称，一些药用植物及其分离化合物具有抗幽门螺杆菌的抗菌活性。其中许多植物提取物和植物衍生化合物的作用机制与传统抗生素不同。因此，它们被证明对耐药性幽门螺杆菌菌株有效。它们通过抑制细菌酶、与胃黏膜的黏附、抑制核因子-κB 和抑制氧化应激来发挥作用。从黄连木、甘蓝、甘草、茶树、肉桂、大蒜和黑种草植物中提取的提取物以及分离的植物化合物，如姜黄素、白藜芦醇、槲皮素、大蒜素和鞣花酸，在体内条件下表现出对幽门螺杆菌的抗菌活性。生姜、甘草的植物提取物；以及植物化学物质大蒜素和小檗碱与标准治疗结合使用时，可显著提高幽门螺杆菌的清除率。在这篇综述中，我们强调了不同植物提取物和分离的植物化合物对幽门螺杆菌感染的治疗效果，并描述了它们在解决幽门螺杆菌对抗生素耐药性方面的作用。
