Department of Oncology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, People's Republic of China.
College of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Nat Prod Res. 2023 Feb;37(4):579-585. doi: 10.1080/14786419.2022.2078817. Epub 2022 May 24.
Two new nor-triterpenoids ganodrenol A (), B (), and a new natural product ganodrenol C (), along with three known nor-triterpenoids (-) were isolated from the fruiting bodies of The chemical structures of these isolates were determined by 1 D and 2 D NMR, HRESIMS, and X-ray crystallography analysis. The inhibitory effects of isolated triterpenoids (-) against FAAH were evaluated by an in assay, and compound showed an inhibition rate of 70.27%. In addition, the cytotoxic effect of compounds (-) was evaluated against LOVO, MCF-7, and RAW264.7 cells, which displayed no significant cytotoxicity.
从灵芝的子实体中分离得到了两个新的 nor-三萜醇 A ()、B () 和一个新的天然产物 ganodrenol C ()，以及三个已知的 nor-三萜醇 (-)。通过 1D 和 2D NMR、HRESIMS 和 X 射线晶体学分析确定了这些分离物的化学结构。通过酶抑制测定法评估了分离得到的三萜醇 (-) 对 FAAH 的抑制作用，化合物 显示出 70.27%的抑制率。此外，还评估了化合物 (-) 对 LOVO、MCF-7 和 RAW264.7 细胞的细胞毒性作用，结果显示它们没有明显的细胞毒性。
