Li Da-Wei, Liu Min, Leng Yue-Qi, Hu Jin-Fang, Deng Sa, Leng Ai-Jing, Ma Xiao-Chi, Wang Ruo-Yu, Zhou Jian, Wang Chao
The Affiliated Zhongshan Hospital of Dalian University, Dalian, 116001, People's Republic of China; The First Affiliated Hospital of Dalian Medical University, Dalian 116011, People's Republic of China.
College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian, 116044, People's Republic of China.
Phytochemistry. 2022 Nov;203:113339. doi: 10.1016/j.phytochem.2022.113339. Epub 2022 Aug 9.
Ganoderma lucidum is a famous edible and medicinal fungus. Through a bioactive phytochemical investigation of the ethanolic extracts of the fruiting bodies of G. lucidum, twenty-nine triterpenoids, including eleven previously undescribed triterpenoids, were isolated and characterized based on spectroscopic data. The inhibitory effects of all the triterpenes against fatty acid amide hydrolase (FAAH) were found to be in the range of 30-60% at 100 μM. Methyl ganoderate A displayed the strongest inhibitory activity (61%) against FAAH. Furthermore, all compounds displayed no cytotoxicity against LOVO and MCF-7 human cancer cells. Hence, our present study provides information about G. lucidum as a functional food or pharmaceutical supplement for the treatment of neuroinflammation.
灵芝是一种著名的食药用真菌。通过对灵芝子实体乙醇提取物进行生物活性植物化学研究，基于光谱数据分离并鉴定了29种三萜类化合物，其中包括11种先前未描述的三萜类化合物。发现所有三萜类化合物在100μM浓度下对脂肪酸酰胺水解酶（FAAH）的抑制作用在30%至60%之间。灵芝酸甲酯A对FAAH表现出最强的抑制活性（61%）。此外，所有化合物对LOVO和MCF-7人癌细胞均无细胞毒性。因此，我们目前的研究提供了有关灵芝作为治疗神经炎症的功能性食品或药物补充剂的信息。
