Chen Shaodan, Li Xiangmin, Yong Tianqiao, Wang Zhanggen, Su Jiyan, Jiao Chunwei, Xie Yizhen, Yang Burton B
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangzhou, China.
Yuewei Edible Fungi Technology Co. Ltd., Guangzhou, China.
Oncotarget. 2017 Feb 7;8(6):10071-10084. doi: 10.18632/oncotarget.14336.
We conducted a study of Ganoderma lucidum metabolites and isolated 35 lanostane-type triterpenoids, including 5 new ganoderols (1-5). By spectroscopy, we compared the structures of these compounds with known related compounds in this group. All of the isolated compounds were assayed for their effect against the human breast carcinoma cell line MDA-MB-231 and hepatocellular carcinoma cell line HepG2. Corresponding three-dimensional quantitative structure-activity relationship (3D-QSAR) models were built and analyzed using Discovery Studio. These results provide further evidence for anti-cancer constituents within Ganoderma lucidum, and may provide a theoretical foundation for designing novel therapeutic compounds.
我们对灵芝代谢产物进行了一项研究，分离出35种羊毛甾烷型三萜类化合物，包括5种新的灵芝醇（1-5）。通过光谱学，我们将这些化合物的结构与该类已知相关化合物进行了比较。对所有分离出的化合物进行了抗人乳腺癌细胞系MDA-MB-231和肝癌细胞系HepG2作用的测定。使用Discovery Studio构建并分析了相应的三维定量构效关系（3D-QSAR）模型。这些结果为灵芝中的抗癌成分提供了进一步的证据，并可能为设计新型治疗化合物提供理论基础。
