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一名年轻女性在莱姆病发病6年后出现局灶性脑炎:三期莱姆病?

Focal encephalitis in a young woman 6 years after the onset of Lyme disease: tertiary Lyme disease?

作者信息

Broderick J P, Sandok B A, Mertz L E

出版信息

Mayo Clin Proc. 1987 Apr;62(4):313-6. doi: 10.1016/s0025-6196(12)61910-7.

DOI:10.1016/s0025-6196(12)61910-7
PMID:3561045
Abstract

A 19-year-old woman had severe focal inflammatory encephalitis. Six years previously, she had had classic untreated Lyme disease characterized by erythema chronicum migrans, bilateral facial palsies, and lymphocytic meningitis. During her recent encephalitic illness, Lyme disease serologic tests were positive by indirect immunofluorescence microscopy, enzyme-linked immunosorbent assay, and western blot (immunoblot technique) testing. We hypothesize that the patient's focal inflammatory encephalitis was a result of a persistent spirochetal infection of the central nervous system.

摘要

一名19岁女性患有严重的局灶性炎性脑炎。六年前,她患过未经治疗的典型莱姆病,其特征为慢性游走性红斑、双侧面神经麻痹和淋巴细胞性脑膜炎。在她最近的脑炎疾病期间,通过间接免疫荧光显微镜检查、酶联免疫吸附测定和蛋白质印迹(免疫印迹技术)检测,莱姆病血清学检测呈阳性。我们推测该患者的局灶性炎性脑炎是中枢神经系统持续性螺旋体感染的结果。

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Focal encephalitis in a young woman 6 years after the onset of Lyme disease: tertiary Lyme disease?一名年轻女性在莱姆病发病6年后出现局灶性脑炎:三期莱姆病?
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引用本文的文献

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Antibiotics (Basel). 2019 Dec 16;8(4):269. doi: 10.3390/antibiotics8040269.
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Is neuroborreliosis a medical emergency?神经莱姆病是一种医疗急症吗?
Neurocrit Care. 2006;4(3):260-6. doi: 10.1385/NCC:4:3:260.
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Lyme disease of the brainstem.脑干莱姆病
Neuroradiology. 2005 Dec;47(12):903-7. doi: 10.1007/s00234-005-1440-2. Epub 2005 Sep 13.
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Neuropsychological functioning in chronic Lyme disease.慢性莱姆病中的神经心理功能
Neuropsychol Rev. 2002 Sep;12(3):153-77. doi: 10.1023/a:1020381913563.
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The neurological complications of Borrelia burgdorferi in the New Forest area of Hampshire.汉普郡新森林地区伯氏疏螺旋体的神经并发症
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Long-term persistence of specific T- and B-lymphocyte responses to Borrelia burgdorferi following untreated neuroborreliosis.未经治疗的神经莱姆病后,针对伯氏疏螺旋体的特异性T淋巴细胞和B淋巴细胞反应的长期持续存在。
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Neurological manifestations of Lyme borreliosis.
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