• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

9型旋转分泌系统的设计原理

Design Principles of the Rotary Type 9 Secretion System.

作者信息

Trivedi Abhishek, Gosai Jitendrapuri, Nakane Daisuke, Shrivastava Abhishek

机构信息

School of Life Sciences, Arizona State University, Tempe, AZ, United States.

Biodesign Center for Fundamental and Applied Microbiomics, Arizona State University, Tempe, AZ, United States.

出版信息

Front Microbiol. 2022 May 10;13:845563. doi: 10.3389/fmicb.2022.845563. eCollection 2022.

DOI:10.3389/fmicb.2022.845563
PMID:35620107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9127263/
Abstract

The F ATP synthase, the bacterial flagellar motor, and the bacterial type 9 secretion system (T9SS) are the three known proton motive force driven biological rotary motors. In this review, we summarize the current information on the nuts and bolts of T9SS. Torque generation by T9SS, its role in gliding motility of bacteria, and the mechanism which a T9SS-driven swarm shapes the microbiota are discussed. The knowledge gaps in our current understanding of the T9SS machinery are outlined.

摘要

F型ATP合酶、细菌鞭毛马达和细菌9型分泌系统(T9SS)是已知的三种由质子动力驱动的生物旋转马达。在本综述中,我们总结了目前关于T9SS基本组成部分的信息。讨论了T9SS产生扭矩的机制、其在细菌滑行运动中的作用以及T9SS驱动的群体塑造微生物群的机制。概述了我们目前对T9SS机制理解中的知识空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/ebb37188e5ee/fmicb-13-845563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/cf3ba56c817c/fmicb-13-845563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/476bf618d281/fmicb-13-845563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/ebb37188e5ee/fmicb-13-845563-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/cf3ba56c817c/fmicb-13-845563-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/476bf618d281/fmicb-13-845563-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08dc/9127263/ebb37188e5ee/fmicb-13-845563-g003.jpg

相似文献

1
Design Principles of the Rotary Type 9 Secretion System.9型旋转分泌系统的设计原理
Front Microbiol. 2022 May 10;13:845563. doi: 10.3389/fmicb.2022.845563. eCollection 2022.
2
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system.一种与分子传送带相关的蛋白质控制细菌9型分泌系统的旋转方向。
mBio. 2025 Jul 9;16(7):e0112525. doi: 10.1128/mbio.01125-25. Epub 2025 Jun 13.
3
A membrane-associated conveyor belt controls the rotational direction of the bacterial type 9 secretion system.一种与膜相关的传送带控制着细菌9型分泌系统的旋转方向。
bioRxiv. 2025 Jan 27:2024.09.23.614571. doi: 10.1101/2024.09.23.614571.
4
Bacterial Swarm-Mediated Phage Transportation Disrupts a Biofilm Inherently Protected from Phage Penetration.细菌群介导的噬菌体运输破坏了固有抗噬菌体穿透的生物膜。
Microbiol Spectr. 2023 Aug 17;11(4):e0093723. doi: 10.1128/spectrum.00937-23. Epub 2023 Jun 26.
5
Unveiling the Molecular Mechanisms of the Type-IX Secretion System's Response Regulator: Structural and Functional Insights.揭示IX型分泌系统响应调节因子的分子机制:结构与功能见解
bioRxiv. 2024 May 15:2024.05.15.594396. doi: 10.1101/2024.05.15.594396.
6
Theoretical insights into rotary mechanism of MotAB in the bacterial flagellar motor.MotAB 在细菌鞭毛马达中旋转机制的理论见解。
Biophys J. 2024 Oct 15;123(20):3587-3599. doi: 10.1016/j.bpj.2024.09.010. Epub 2024 Sep 11.
7
Scrutinizing Stator Rotation in the Bacterial Flagellum: Reconciling Experiments and Switching Models.审视细菌鞭毛中的定子旋转:协调实验与切换模型
Biomolecules. 2025 Mar 1;15(3):355. doi: 10.3390/biom15030355.
8
In situ structure of a bacterial flagellar motor at subnanometre resolution reveals adaptations for increased torque.细菌鞭毛马达亚纳米分辨率的原位结构揭示了增加扭矩的适应性。
Nat Microbiol. 2025 Jul;10(7):1723-1740. doi: 10.1038/s41564-025-02012-9. Epub 2025 Jul 1.
9
Mapping the loss of flagellar motility across the tree of life.描绘生命之树上鞭毛运动能力丧失的情况。
ISME J. 2025 Jan 2;19(1). doi: 10.1093/ismejo/wraf111.
10
Molecular mechanism for rotational switching of the bacterial flagellar motor.细菌鞭毛马达旋转切换的分子机制。
Nat Struct Mol Biol. 2020 Nov;27(11):1041-1047. doi: 10.1038/s41594-020-0497-2. Epub 2020 Sep 7.

引用本文的文献

1
Advances in the type IX secretion system: an exploration focusing on .IX型分泌系统的进展:聚焦于……的探索
Curr Res Microb Sci. 2025 May 12;9:100404. doi: 10.1016/j.crmicr.2025.100404. eCollection 2025.
2
Structure of the T9SS PorKN ring complex reveals conformational plasticity based on the repurposed FGE fold.T9分泌系统PorKN环复合物的结构揭示了基于重新利用的FGE折叠的构象可塑性。
mBio. 2025 Sep 10;16(9):e0179925. doi: 10.1128/mbio.01799-25. Epub 2025 Aug 7.
3
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system.

本文引用的文献

1
Bacterial Swarm-Mediated Phage Transportation Disrupts a Biofilm Inherently Protected from Phage Penetration.细菌群介导的噬菌体运输破坏了固有抗噬菌体穿透的生物膜。
Microbiol Spectr. 2023 Aug 17;11(4):e0093723. doi: 10.1128/spectrum.00937-23. Epub 2023 Jun 26.
2
Dynamic proton-dependent motors power type IX secretion and gliding motility in Flavobacterium.动态质子依赖型马达为黄杆菌属中的IX型分泌和滑行运动提供动力。
PLoS Biol. 2022 Mar 25;20(3):e3001443. doi: 10.1371/journal.pbio.3001443. eCollection 2022 Mar.
3
Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon.
一种与分子传送带相关的蛋白质控制细菌9型分泌系统的旋转方向。
mBio. 2025 Jul 9;16(7):e0112525. doi: 10.1128/mbio.01125-25. Epub 2025 Jun 13.
4
Beyond pathogenicity: the immunomodulatory role of the type III secretion system in beneficial plant-microbe interactions.超越致病性:III型分泌系统在有益植物-微生物相互作用中的免疫调节作用
Open Biol. 2025 May;15(5):240318. doi: 10.1098/rsob.240318. Epub 2025 May 28.
5
C-terminal glycosylation of type IX secretion system cargo proteins in with both short and long secretion signals.具有短分泌信号和长分泌信号的IX型分泌系统货物蛋白的C端糖基化
Open Biol. 2025 Mar;15(3):240335. doi: 10.1098/rsob.240335. Epub 2025 Mar 26.
6
Swarming bacteria exhibit developmental phase transitions to establish scattered colonies in new regions.群体游动细菌会经历发育阶段转变,以便在新区域形成分散的菌落。
ISME J. 2025 Jan 2;19(1). doi: 10.1093/ismejo/wrae263.
7
The prevalence of motility-related genes within the human oral microbiota.人类口腔微生物群中与运动性相关基因的流行情况。
Microbiol Spectr. 2025 Jan 7;13(1):e0126424. doi: 10.1128/spectrum.01264-24. Epub 2024 Dec 9.
8
A molecular toolkit for heterologous protein secretion across Bacteroides species.用于跨拟杆菌属物种异源蛋白分泌的分子工具包。
Nat Commun. 2024 Nov 11;15(1):9741. doi: 10.1038/s41467-024-53845-7.
9
Structural insights into the disulfide isomerase and chaperone activity of TrbB of the F plasmid type IV secretion system.F质粒IV型分泌系统TrbB的二硫键异构酶和伴侣活性的结构见解
Curr Res Struct Biol. 2024 Jul 14;8:100156. doi: 10.1016/j.crstbi.2024.100156. eCollection 2024.
10
Ecological, beneficial, and pathogenic functions of the Type 9 Secretion System.9 型分泌系统的生态、有益和致病功能。
Microb Biotechnol. 2024 Jun;17(6):e14516. doi: 10.1111/1751-7915.14516.
IX 型分泌系统的蛋白质互作组分析鉴定出 PorW 是 PorK/N 环复合物与 Sov 转位器之间缺失的连接蛋白。
Microbiol Spectr. 2022 Feb 23;10(1):e0160221. doi: 10.1128/spectrum.01602-21. Epub 2022 Jan 12.
4
Social motility of biofilm-like microcolonies in a gliding bacterium.滑动细菌中生物膜样微菌落的社会运动性。
Nat Commun. 2021 Sep 29;12(1):5700. doi: 10.1038/s41467-021-25408-7.
5
The Type 9 Secretion System Is Required for Biofilm Formation.生物膜形成需要IX型分泌系统。
Front Microbiol. 2021 Sep 2;12:660887. doi: 10.3389/fmicb.2021.660887. eCollection 2021.
6
A Widespread Bacterial Secretion System with Diverse Substrates.一种具有多种底物的广泛细菌分泌系统。
mBio. 2021 Aug 31;12(4):e0195621. doi: 10.1128/mBio.01956-21. Epub 2021 Aug 17.
7
Structure of the molecular bushing of the bacterial flagellar motor.细菌鞭毛马达的分子套管结构。
Nat Commun. 2021 Jul 22;12(1):4469. doi: 10.1038/s41467-021-24715-3.
8
Structure of the mycobacterial ESX-5 type VII secretion system pore complex.分枝杆菌ESX-5 VII型分泌系统孔复合体的结构
Sci Adv. 2021 Jun 25;7(26). doi: 10.1126/sciadv.abg9923. Print 2021 Jun.
9
Type VII secretion systems: structure, functions and transport models.VII 型分泌系统:结构、功能和运输模型。
Nat Rev Microbiol. 2021 Sep;19(9):567-584. doi: 10.1038/s41579-021-00560-5. Epub 2021 May 26.
10
Large-Scale Vortices with Dynamic Rotation Emerged from Monolayer Collective Motion of Gliding .滑动平面单层集体运动产生的大尺度涡旋及其动态旋转
J Bacteriol. 2021 Jun 22;203(14):e0007321. doi: 10.1128/JB.00073-21.