Pliakou Evangelia, Lampropoulou Dimitra Ioanna, Nasi Despoina, Aravantinos Gerasimos
Second Department of Medical Oncology, General Oncology Hospital of Kifissia 'Agioi Anargiroi', Athens 14564, Greece.
Mol Clin Oncol. 2022 Jun;16(6):110. doi: 10.3892/mco.2022.2543. Epub 2022 May 11.
Gastric cancer (GC) is the fifth most commonly diagnosed malignancy and the fourth leading cause of cancer death worldwide. Skin metastases from internal organs are rare; skin metastasis from GC occurs even more rarely than skin metastases originating from other organs, and is associated with systematic disease and poor prognosis. The present study described an interesting and rare case of an extensive skin rash in a 42-year-old man diagnosed with GC, which was mainly affecting his left hemithorax, abdomen and back. The rash masqueraded as erysipelas and was initially treated as such; however, it did not respond to antibiotics, corticosteroids and antihistamines. Due to its persistence and location, the rash was biopsied and GC metastasis was confirmed. Third-line chemotherapy was administered and the rash decreased in size; however, the patient suffered from disease deterioration with lung metastases and respiratory failure. The patient eventually died 4 months after the diagnosis of skin metastasis. In conclusion, cutaneous metastasis should be considered as a late and difficult to treat metastasis of GC, which requires high surveillance from medical oncologists, and a multidisciplinary approach for prompt and accurate diagnosis.
胃癌（GC）是全球第五大最常被诊断出的恶性肿瘤，也是癌症死亡的第四大主要原因。来自内脏器官的皮肤转移很少见；胃癌的皮肤转移比源自其他器官的皮肤转移更为罕见，并且与全身性疾病及预后不良相关。本研究描述了一例有趣且罕见的病例，一名42岁被诊断为胃癌的男性出现广泛皮疹，主要累及左半胸、腹部和背部。该皮疹伪装成丹毒，最初也按此进行治疗；然而，它对抗生素、皮质类固醇和抗组胺药均无反应。由于皮疹持续存在且位置特殊，遂进行活检，确诊为胃癌转移。给予三线化疗后皮疹尺寸减小；然而，患者病情恶化，出现肺转移和呼吸衰竭。患者最终在皮肤转移诊断后4个月死亡。总之，皮肤转移应被视为胃癌晚期且难以治疗的转移，这需要肿瘤内科医生高度警惕，并采用多学科方法进行及时准确的诊断。
