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1
Conformational stability of alternating d (CG) oligomers in high salt solution.交替的d（CG）寡聚物在高盐溶液中的构象稳定性。
Nucleic Acids Res. 1981 May 11;9(9):2195-206. doi: 10.1093/nar/9.9.2195.
2
Simultaneous stability of short alternating Z and B helices in synthetic DNA concatamers.合成DNA串联体中短交替Z螺旋和B螺旋的同时稳定性。
Nucleic Acids Res. 1982 Jun 25;10(12):3759-68. doi: 10.1093/nar/10.12.3759.
3
Effect of P-chirality of internucleotide bonds on B-Z conversion of stereodefined self-complementary phosphorothioate oligonucleotides of the [PS]-d(CG)4 and [PS]-d(GC)4 series.核苷酸间键的P-手性对[PS]-d(CG)4和[PS]-d(GC)4系列立体定向自互补硫代磷酸酯寡核苷酸B-Z转换的影响。
Biochemistry. 2000 Sep 12;39(36):11057-64. doi: 10.1021/bi000638n.
4
Short oligodeoxynucleotides with d(G-C)n sequence do not assume left-handed conformation in high salt conditions.具有d(G-C)n序列的短寡脱氧核苷酸在高盐条件下不会呈现左手构象。
J Mol Biol. 1984 May 25;175(3):419-23. doi: 10.1016/0022-2836(84)90358-9.
5
Spectroscopic studies of (m5dC-dG)3: thermal stability of B- and Z-forms.（m5dC-dG）3的光谱研究：B型和Z型的热稳定性
Nucleic Acids Res. 1983 Jul 11;11(13):4453-66. doi: 10.1093/nar/11.13.4453.
6
Conformational transitions of poly(dA-dC).poly(dG-dT) induced by high salt or in ethanolic solution.高盐或乙醇溶液诱导的聚（dA-dC）·聚（dG-dT）的构象转变
Nucleic Acids Res. 1982 Feb 11;10(3):1081-91. doi: 10.1093/nar/10.3.1081.
7
L-nucleotides and 8-methylguanine of d(C1m8G2C3G4C5LG6LC7G8C9G10)2 act cooperatively to promote a left-handed helix under physiological salt conditions.d(C1m8G2C3G4C5LG6LC7G8C9G10)2 的 L-核苷酸和 8-甲基鸟嘌呤在生理盐条件下协同作用以促进左手螺旋的形成。
Nucleic Acids Res. 2003 Dec 1;31(23):6986-95. doi: 10.1093/nar/gkg893.
8
Synthesis and physical characterization of the self-complementary, alternating pyrimidine/purine hexanucleotide d[CGTACG].自我互补交替嘧啶/嘌呤六核苷酸d[CGTACG]的合成与物理表征
Nucleic Acids Res. 1982 Oct 25;10(20):6265-71. doi: 10.1093/nar/10.20.6265.
9
The left-handed Z-DNA conformation in oligodeoxynucleotides containing different amounts of AT base pairs: a far UV circular dichroism study.含不同数量AT碱基对的寡脱氧核苷酸中的左手Z-DNA构象：远紫外圆二色性研究
J Biomol Struct Dyn. 1989 Jun;6(6):1217-31. doi: 10.1080/07391102.1989.10506546.
10
A temperature-dependent Z to B to single-strand transition in d(CGCG).d（CGCG）中存在温度依赖的Z型到B型再到单链的转变。
Biopolymers. 1989 Sep;28(9):1625-36. doi: 10.1002/bip.360280911.

引用本文的文献

1
L-DNAs as potential antimessenger oligonucleotides: a reassessment.L-DNAs作为潜在的反信使寡核苷酸：重新评估
Nucleic Acids Res. 1993 Sep 11;21(18):4159-65. doi: 10.1093/nar/21.18.4159.
2
Analysis of oligonucleotide structure using hyperchromism measurements at long wavelengths.利用长波长下的增色测量分析寡核苷酸结构。
Nucleic Acids Res. 1993 Aug 11;21(16):3907-8. doi: 10.1093/nar/21.16.3907.
3
Infrared CD of deoxy oligonucleotides. Conformational studies of 5'd(GCGC)3', 5'd(CGCG)3', 5'd(CCGG)3', and 5'd(GGCC)3' in low and high salt aqueous solution.脱氧寡核苷酸的红外圆二色性。5'd(GCGC)3'、5'd(CGCG)3'、5'd(CCGG)3'和5'd(GGCC)3'在低盐和高盐水溶液中的构象研究。
Biophys J. 1993 Sep;65(3):1262-71. doi: 10.1016/S0006-3495(93)81176-7.
4
The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.聚（dG-dC）·聚（dG-dC）的高盐形式是左手Z-DNA：晶体和溶液的拉曼光谱。
Nucleic Acids Res. 1981 Oct 24;9(20):5443-57. doi: 10.1093/nar/9.20.5443.
5
Synthesis and physical characterization of the self-complementary, alternating pyrimidine/purine hexanucleotide d[CGTACG].自我互补交替嘧啶/嘌呤六核苷酸d[CGTACG]的合成与物理表征
Nucleic Acids Res. 1982 Oct 25;10(20):6265-71. doi: 10.1093/nar/10.20.6265.
6
The influence of the purine 2-amino group on DNA conformation and stability. Synthesis and conformational analysis of d[T(2-aminoA)]3.嘌呤2-氨基对DNA构象和稳定性的影响。d[T(2-氨基A)]3的合成与构象分析。
Nucleic Acids Res. 1982 Jul 24;10(14):4351-61. doi: 10.1093/nar/10.14.4351.
7
Simultaneous stability of short alternating Z and B helices in synthetic DNA concatamers.合成DNA串联体中短交替Z螺旋和B螺旋的同时稳定性。
Nucleic Acids Res. 1982 Jun 25;10(12):3759-68. doi: 10.1093/nar/10.12.3759.
8
Spectroscopic studies of (m5dC-dG)3: thermal stability of B- and Z-forms.（m5dC-dG）3的光谱研究：B型和Z型的热稳定性
Nucleic Acids Res. 1983 Jul 11;11(13):4453-66. doi: 10.1093/nar/11.13.4453.
9
Interaction of diamidino-2-phenylindole (DAPI) with natural and synthetic nucleic acids.二脒基-2-苯基吲哚（DAPI）与天然和合成核酸的相互作用。
Nucleic Acids Res. 1983 Dec 20;11(24):8861-76. doi: 10.1093/nar/11.24.8861.
10
31P-NMR analysis of the B to Z transition in double-stranded (dC-dG)3 and (dC-dG)4 in high salt solution.高盐溶液中双链(dC-dG)3和(dC-dG)4从B型向Z型转变的31P核磁共振分析。
Nucleic Acids Res. 1984 Jun 11;12(11):4625-35. doi: 10.1093/nar/12.11.4625.

本文引用的文献

1
Left-handed double helical DNA: variations in the backbone conformation.左手双螺旋DNA：主链构象的变化
Science. 1981 Jan 9;211(4478):171-6. doi: 10.1126/science.7444458.
2
DNA-like duplexes with repetitions. I. Properties of concatemer duplexes formed by d(T-G-C-A-C-A-T-G).具有重复序列的类DNA双链体。I. 由d(T-G-C-A-C-A-T-G)形成的多联体双链体的性质
Nucleic Acids Res. 1980 Jun 11;8(11):2413-29. doi: 10.1093/nar/8.11.2413.
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Crystal structure analysis of a complete turn of B-DNA.B型DNA完整一圈的晶体结构分析。
Nature. 1980 Oct 23;287(5784):755-8. doi: 10.1038/287755a0.
4
High-salt d(CpGpCpG), a left-handed Z' DNA double helix.高盐条件下的d（CpGpCpG），一种左手Z'型DNA双螺旋结构。
Nature. 1980 Aug 7;286(5773):567-73. doi: 10.1038/286567a0.
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Left-handed DNA helices.左手DNA螺旋
Nature. 1980 Feb 21;283(5749):743-5. doi: 10.1038/283743a0.
6
The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.四聚体d（CpGpCpG）结晶为左手双螺旋结构。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4016-20. doi: 10.1073/pnas.77.7.4016.
7
Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).盐诱导的合成DNA的协同构象变化：聚（dG-dC）的平衡和动力学研究
J Mol Biol. 1972 Jun 28;67(3):375-96. doi: 10.1016/0022-2836(72)90457-3.
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Polymorphism of a synthetic DNA in solution.溶液中合成DNA的多态性。
Nature. 1976 Mar 25;260(5549):365-6. doi: 10.1038/260365a0.
9
Molecular structure of a left-handed double helical DNA fragment at atomic resolution.原子分辨率下左手双螺旋DNA片段的分子结构。
Nature. 1979 Dec 13;282(5740):680-6. doi: 10.1038/282680a0.
10
A hypothesis on a specific sequence-dependent conformation of DNA and its relation to the binding of the lac-repressor protein.关于DNA特定序列依赖性构象及其与乳糖阻遏蛋白结合关系的一种假说。
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交替的d（CG）寡聚物在高盐溶液中的构象稳定性。

Conformational stability of alternating d (CG) oligomers in high salt solution.

作者信息

Quadrifoglio F, Manzini G, Vasser M, Dinkelspiel K, Crea R

出版信息

Nucleic Acids Res. 1981 May 11;9(9):2195-206. doi: 10.1093/nar/9.9.2195.

DOI:10.1093/nar/9.9.2195
PMID:6272229
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326835/
Abstract

The conformation of d (CG)n oligomers with n = 2,3 has been studied in aqueous solution in the presence of high salt concentration. A minimum n value of three is necessary to obtain a left-handed Z-helix. When d (CG)3 is flanked by three non Z-helicogenic alternating AT sequences the left-handed helix is unstable and a B-type conformation is obtained also at high salt concentration.

摘要

已在高盐浓度存在的情况下，对n = 2、3时的d（CG）n寡聚物在水溶液中的构象进行了研究。要获得左手Z型螺旋，n的最小值为3。当d（CG）3两侧有三个非Z螺旋形成性交替AT序列时，左手螺旋不稳定，即使在高盐浓度下也会获得B型构象。