Department of Psychiatry, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, United States.
Department of Psychiatry, University of California, San Diego Health, 9500 Gilman Drive, La Jolla, CA 92093, United States.
J Neurosci Methods. 2022 Jul 15;377:109631. doi: 10.1016/j.jneumeth.2022.109631. Epub 2022 May 24.
Biomarkers are essential for understanding the underlying pathologies in brain disorders and for developing effective treatments. Combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) is an emerging neurophysiological tool that can be used for biomarker development. This method can identify biomarkers associated with the function and dynamics of the inhibitory and excitatory neurotransmitter systems and effective connectivity between brain areas. In this review, we outline the current state of the TMS-EEG biomarker field by summarizing the existing protocols and the possibilities and challenges associated with this methodology.
生物标志物对于理解脑部疾病的潜在病理机制以及开发有效的治疗方法至关重要。经颅磁刺激与脑电图（TMS-EEG）结合是一种新兴的神经生理学工具，可用于开发生物标志物。该方法可识别与抑制性和兴奋性神经递质系统的功能和动力学以及脑区之间的有效连接相关的生物标志物。在这篇综述中，我们通过总结现有的方案以及该方法的可能性和挑战，概述了 TMS-EEG 生物标志物领域的现状。
